A0A504XCF9 · A0A504XCF9_LEIDO

  • Protein
    ATP-dependent DNA helicase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Has an integral role during the infection of macrophages in the mammalian host.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site733Zn2+ (UniProtKB | ChEBI); catalytic
Active site734
Binding site737Zn2+ (UniProtKB | ChEBI); catalytic
Binding site803Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA helicase activity
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological Processproteolysis
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase
  • EC number

Gene names

    • ORF names
      CGC21_23665

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FDAARGOS_361
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    A0A504XCF9

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region126-156Disordered
Region196-220Disordered
Compositional bias202-220Polar residues
Region262-343Disordered
Compositional bias289-306Basic and acidic residues
Compositional bias318-343Polar residues

Sequence similarities

Belongs to the helicase family. PIF1 subfamily.
Belongs to the peptidase M8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,071
  • Mass (Da)
    113,030
  • Last updated
    2019-09-18 v1
  • Checksum
    A1A1087FB9D7504C
MGPLVSAPGLLASLSVPRPAVLRQRTPAQLMRTAHPEAKYFARGGRQERQPKLHRRRAAVRGGGAAGGSLNTRAAAHAAADAEGAHSVHGVYSNVRGAARHHVTVSGTAATGARDRDAVLLRLSDSDTAQDGLRPGQAREGAVGGRTASPVGGGGVTRECTTTAVAAPKAAVSTSTLPPPRVPPTALRTAVSVVVGSGADPRDNSENLQNPRPPQTSSVMLDPTQAKAVDLAVRGFNIFVTGGAGTGKSQTLRAIVAALRSREVHESEETLRAVASAADSPQRGGSGRRAGARESDVAREEGRSVQRGFAEPSPPSRLSELSRATTSASRSSPRSSSAARAVPALSSVCATATTGLAAMQLHGVAINTFAGVGPGRGTPGQPLRTVQKNAEAAQRWRRCRVLLIDEVSMPEASLLEPLDYIAHRVRRCTNVPSGGMQVILCGVSFQLPPIAGRGGLWCWRTTSSSRPLWTRRRKRRPRACRAMSVDSSSTHRHRSVAARLVRLAAAGAAVIAAVGTAAAWAHAGAVQHRCIHDAMQARVRQSVARHHTAPGAVSAVGLSYVTLGAAPTVVRAANWGALRIAVSTEDLTDPAYHCARVGQRISTRDGRFAICTAEDILTDEKRDILVKHLIPQALQLHTERLKVRQVQDKWKVTGMGDDVCSDFKVPPAHITDGLSNTDFVMYVASVPSEGDVLAWATTCQVFSDGHPAVGVVNIPAANIASRYDQLVTRVVTHEMAHALGFSVGFFEGARILENISNVRHKDFDVPVINSSTAVAKAREQYGCDTLEYLEIEDQGGAGSAGSHIKMRNAQDELMAPAAAAGYYSALTMAIFQDLGFYQADFSKAEEMPWGRNAGCAFLSEKCMEDGITKWPAMFCNENEVTMRCPTSRLGLGKCGVTRHPDLPPYWQYFTDPSLAGISAFMDCCPVVEPYGDGSCAQRASEAGAPFKGFNVFSDAARCIDGAFRPKTSHGIIKSYAGLCANVRCDTATRTYSVQVHGGSGYANCTPGLRVELSTVSSAFEEGGYITCPPYVEVCQGNVQAAKDGGNAAAGRRGPRAAATALLVAALLAVAL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias202-220Polar residues
Compositional bias289-306Basic and acidic residues
Compositional bias318-343Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RHLC01000036
EMBL· GenBank· DDBJ
TPP46626.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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