A0A504XCF9 · A0A504XCF9_LEIDO
- ProteinATP-dependent DNA helicase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1071 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Has an integral role during the infection of macrophages in the mammalian host.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 733 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 734 | ||||
Binding site | 737 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 803 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA helicase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | cell adhesion | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | proteolysis | |
Biological Process | telomere maintenance |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionA0A504XCF9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 126-156 | Disordered | |||
Region | 196-220 | Disordered | |||
Compositional bias | 202-220 | Polar residues | |||
Region | 262-343 | Disordered | |||
Compositional bias | 289-306 | Basic and acidic residues | |||
Compositional bias | 318-343 | Polar residues | |||
Sequence similarities
Belongs to the helicase family. PIF1 subfamily.
Belongs to the peptidase M8 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,071
- Mass (Da)113,030
- Last updated2019-09-18 v1
- ChecksumA1A1087FB9D7504C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 202-220 | Polar residues | |||
Compositional bias | 289-306 | Basic and acidic residues | |||
Compositional bias | 318-343 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
RHLC01000036 EMBL· GenBank· DDBJ | TPP46626.1 EMBL· GenBank· DDBJ | Genomic DNA |