A0A4Y9EJX3 · A0A4Y9EJX3_9SPHN

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site118Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site119Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site157substrate
Binding site183substrate
Site193-194Cleavage; by autolysis
Active site194Nucleophile
Binding site194substrate
Binding site281substrate
Binding site404substrate
Binding site409substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      EUV02_11985

Organism names

  • Taxonomic identifier
  • Strain
    • DJ1R-1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingosinicellaceae > Polymorphobacter

Accessions

  • Primary accession
    A0A4Y9EJX3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50235474961-193Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023547497194-409Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    41,467
  • Last updated
    2019-09-18 v1
  • Checksum
    0DAA5914DA121D5C
MTISPLAQPFPAMPPVAGVRLAVARAGYKAWDRADLTLAELAPGTSVAGVTTRSKCPSPEVDWCRSALPQGRARVLVVNAGNSNAFTGKAGEAAVQAVVSAAVTAFDCTPHQVFVASTGVIGVPLSAAKARAGVADAASRLASDPADYIDAANAIGTTDTFAKGATASAIVDGKRIVINGIVKGSGMIAPDMATMLGFIFTDAAVAPDFLQMALTQATATSFNAITVDSDTSTSDTVLAFATSAAGNAEITSYACPGADAFAAALQDVCTQLALLVVRDGEGATKLITVDVEGAEDDRAAKVVALSIANSPLVKTAIAGGDANWGRVVMAVGKAGEAADRDRLDISFGATLVAQDGAVVPGYDEAPVAAHLAGDEVSIHVDLKLGDGRARVWTCDLTHGYISINADYRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SIHO01000003
EMBL· GenBank· DDBJ
TFU01031.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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