A0A4Y5RE15 · A0A4Y5RE15_9FLAV
- ProteinGenome polyprotein
- GenePOLY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2633 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A4Y5RE15
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 399-418 | Helical | ||||
Sequence: MLMTGTLAVFFLLIMGQLTW | ||||||
Transmembrane | 442-462 | Helical | ||||
Sequence: YLALMATFKMRPMFAVGLLFR | ||||||
Transmembrane | 535-553 | Helical | ||||
Sequence: TMAMVLSIVSLFPLCLSTT | ||||||
Transmembrane | 559-578 | Helical | ||||
Sequence: WLPVLLGSLGCKPLTMFLIA | ||||||
Transmembrane | 614-631 | Helical | ||||
Sequence: LAGPLIAGGMLIACYVIS | ||||||
Transmembrane | 683-710 | Helical | ||||
Sequence: ILLKATLLAVSGVYPLSIPATLFVWYFW | ||||||
Transmembrane | 1390-1409 | Helical | ||||
Sequence: LMLLALIAVLTGGVTLFFLS | ||||||
Transmembrane | 1416-1433 | Helical | ||||
Sequence: TSIGLLCVMASSVLLWMA | ||||||
Transmembrane | 1439-1456 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 1468-1485 | Helical | ||||
Sequence: QLAYVVIGLLFMILTVAA |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 587-716 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAVGIVSILLSPLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPLSIPATLFVWYFWQKKKQR | ||||||
Domain | 717-894 | Peptidase S7 | ||||
Sequence: SGVLWDTPSPPEVERAVLDDGIYRIMQRGLLGRSQVGVGVFQENVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRLQGSWNTGEEVQVIAVEPGKNPKNVQTAPGTFKTPEGEVGAIALDFKPGTSGSPILNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPE | ||||||
Domain | 897-1053 | Helicase ATP-binding | ||||
Sequence: DEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPSSIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEE | ||||||
Domain | 1063-1229 | Helicase C-terminal | ||||
Sequence: SGYEWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNHNKEGDQYIYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 1736-1997 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGAQGETLGEKWKRQLNQLSKSEFNTYKRSGIMEVDRSEAKEGLKRGETTKHAVSRGTAKLRWFVERNLVKPEGKVIDLGCGRGGWSYYCAGLKKVTEVKGYTKGGPGHEEPIPMATYGWNLVKLYSGKDVFFMPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLRGNQFCIKILNPYMPSVVETLEQMQRKHGGMLVRNPLSRNSTHEMYWVSCGTGNIVSAVNMTSRMLLNRFTMAHRKPTYERDVDLGAGTRH | ||||||
Domain | 2261-2410 | RdRp catalytic | ||||
Sequence: GNMYADDTAGWDTRITEDDLQNEAKITDIMEPKHALLAKAIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFSPSELETPNLAKRVLDWLEKYGVERLKRMAISGDDCVVKPIDDRFAAA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length2,633
- Mass (Da)295,679
- Last updated2019-09-18 v1
- ChecksumA82BC687BC05C28E
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I |