A0A4X2MBE5 · A0A4X2MBE5_VOMUR

Function

function

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasement membrane
Cellular Componentelastic fiber
Cellular Componentextracellular space
Molecular Functioncalcium ion binding
Molecular Functionextracellular matrix structural constituent
Molecular Functionfibrinogen binding
Molecular Functionfibronectin binding
Molecular Functionidentical protein binding
Molecular Functionintegrin binding
Molecular Functionpeptidase activator activity
Biological Processblood coagulation, fibrin clot formation
Biological Processextracellular matrix organization
Biological Processnegative regulation of cell motility
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of protein phosphorylation
Biological Processnegative regulation of stem cell proliferation
Biological Processnegative regulation of substrate adhesion-dependent cell spreading

Names & Taxonomy

Protein names

  • Recommended name
    Fibulin-1

Gene names

    • Name
      FBLN1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Diprotodontia > Vombatidae > Vombatus

Accessions

  • Primary accession
    A0A4X2MBE5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_502123085126-702Fibulin-1

Keywords

Interaction

Subunit

Homomultimerizes and interacts with various extracellular matrix components.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-65Anaphylatoxin-like
Domain73-105Anaphylatoxin-like
Domain107-139Anaphylatoxin-like
Domain355-397EGF-like
Domain440-479EGF-like

Sequence similarities

Belongs to the fibulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    702
  • Mass (Da)
    77,283
  • Last updated
    2019-09-18 v1
  • Checksum
    A0C0CAECFEC8C7C8
MEPAWTPRLLALLALVTLLAARATADVLMEDCCADGHRLATQKRDCSVPYASESKECRMVQEQCCQNQLEELHCATGINVAHEGDSCDTHHNNSSFEAKFVKKCCHCCLLGKAAQAQGQSCEYNLMIGYQCGLVYRACCVKSQESAELAPGDVAVPLDTAKIPEEDIVDQEDPYLHDRCRGGGPCTQQCRDTGSTVVCSCFVGYQLLPDGVSCEDTNECITGTHNCRIGEICINTVGTFRCQRESSCGTGYELMEDNTCKDIDECETGIHNCLPTFICQNTPGSFRCRPKLQCRGGFIQDALGNCIDINECLSINAPCPIGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPSEPCGAGHLCINTPGSFRCDCKAGYYFDGISRTCADINECRRYPGRLCGHKCENTPGSYHCSCTIGFKLSSDGRSCEDLNECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGITCEDIDECALPTGGHICSYRCLNVPGSFQCHCPATGYRLAANGRSCQDIDECAAGTHNCSINATCFNIQGSFRCLSFDCPENYRRSGDTIRHEKTDTVRCIKSCRPIDVNCVLDPVHTISHTVISLPTFREFTRPEEIIFLRAVTPAYPANHADIIFDITEGNLRDSFDIIKRYLDGMTVGVVRQIRPIVGPFYVTLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF

Keywords

Genome annotation databases

Similar Proteins

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