A0A4X2KN33 · A0A4X2KN33_VOMUR

Function

function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site222Proton donor
Binding site222-226AMP (UniProtKB | ChEBI)
Binding site226Zn2+ 1 (UniProtKB | ChEBI)
Binding site262Zn2+ 1 (UniProtKB | ChEBI)
Binding site263AMP (UniProtKB | ChEBI)
Binding site263Zn2+ 2 (UniProtKB | ChEBI)
Binding site263Zn2+ 1 (UniProtKB | ChEBI)
Binding site369AMP (UniProtKB | ChEBI)
Binding site369Zn2+ 1 (UniProtKB | ChEBI)
Binding site420AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentneuronal cell body
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processcellular response to granulocyte macrophage colony-stimulating factor stimulus
Biological Processcellular response to macrophage colony-stimulating factor stimulus
Biological Processdopamine catabolic process
Biological Processlocomotory behavior
Biological Processmonocyte differentiation
Biological Processresponse to amphetamine
Biological Processserotonin metabolic process
Biological Processsignal transduction
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE1B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Diprotodontia > Vombatidae > Vombatus

Accessions

  • Primary accession
    A0A4X2KN33

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil38-90
Domain145-504PDEase
Region447-477Disordered
Region497-536Disordered
Compositional bias500-514Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    536
  • Mass (Da)
    61,240
  • Last updated
    2019-09-18 v1
  • Checksum
    33F07A76FEB10507
MELSPGSPQEMLESDCTSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSNAVINCLKTLDHWCFDVFALNRVADDHALRTIVFELLTRHNLISRFKLPTVFLMTFLDALEVGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRSLVIEMVLATDMSCHFQQVKSMKTSLQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLVDEGSKAKTKPSSQWYQPSLDGSREPGDLNPDLVSFRTTWTKYIQENKQKWKERAASGITNQTSIDELSPCEEEAPSSPAEELNQNGNLD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4X2KG02A0A4X2KG02_VOMURPDE1B517

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias500-514Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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