A0A4X2KHE4 · A0A4X2KHE4_VOMUR
- ProteinFrizzled-6
- GeneFZD6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids712 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | apicolateral plasma membrane | |
Cellular Component | cell surface | |
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | ubiquitin protein ligase binding | |
Molecular Function | Wnt receptor activity | |
Molecular Function | Wnt-protein binding | |
Biological Process | cell proliferation in midbrain | |
Biological Process | embryonic nail plate morphogenesis | |
Biological Process | establishment of body hair planar orientation | |
Biological Process | hair follicle development | |
Biological Process | inner ear morphogenesis | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | neural tube closure | |
Biological Process | platelet activation | |
Biological Process | Wnt signaling pathway, planar cell polarity pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameFrizzled-6
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Diprotodontia > Vombatidae > Vombatus
Accessions
- Primary accessionA0A4X2KHE4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Cytoplasmic vesicle membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 201-222 | Helical | ||||
Sequence: FIGIVSIFCLCATLFTFLTFLI | ||||||
Transmembrane | 234-254 | Helical | ||||
Sequence: IIYYSVCYSIVSLMYFIGFLL | ||||||
Transmembrane | 284-312 | Helical | ||||
Sequence: VLFMLLYFFTMAGTVWWVILTITWFLAAG | ||||||
Transmembrane | 324-345 | Helical | ||||
Sequence: AVWFHAVAWGMPGFLTVMLLAM | ||||||
Transmembrane | 369-393 | Helical | ||||
Sequence: YFVLLPLCLCVFVGLSLLLAGIISL | ||||||
Transmembrane | 413-438 | Helical | ||||
Sequence: FMIRIGVFSGLYLVPLVTLLGCYVYE | ||||||
Transmembrane | 473-494 | Helical | ||||
Sequence: LALFMIKYLMTLIVGISAVFWV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: METVLFFVMCITLPLIRG | ||||||
Chain | PRO_5021339361 | 19-712 | Frizzled-6 | |||
Sequence: HSFFTCEPITVPKCVKMTYNMTFFPNLMGHYDQSIAALEMEPFLPLANLHCSPDVDTFLCNAFVPACTEQIHVVPPCRKFCERVYSDCKYLIDTFGITWPEELECSRLQYCDETAPVASDLTTKFHDPPKTPQQVQRDYGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKNDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGNSTACNKADEKLELGETVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVGLYDLYASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQIYRIIWETTWVSDHCHRYHIPCPHQAKTLARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWASFFNRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKSSSHKLKVISKSMGTSTGATANHGTSAVAIANHDCLGQENLTEIKTSPEASVRDMGADGSSLQKARENNVGEHTSPADSSSKLSVEQVERRCKTGNSNDKSSVSGSVWSEGRVTPKANFTETHLLQSSNLQIPSTSQPGSPKGSTSLLIHSTLDTGKEQSSGNNSDT | ||||||
Disulfide bond | 24↔85 | |||||
Sequence: CEPITVPKCVKMTYNMTFFPNLMGHYDQSIAALEMEPFLPLANLHCSPDVDTFLCNAFVPAC | ||||||
Disulfide bond | 32↔78 | |||||
Sequence: CVKMTYNMTFFPNLMGHYDQSIAALEMEPFLPLANLHCSPDVDTFLC | ||||||
Disulfide bond | 99↔123 | |||||
Sequence: CERVYSDCKYLIDTFGITWPEELEC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-132 | FZ | ||||
Sequence: HSFFTCEPITVPKCVKMTYNMTFFPNLMGHYDQSIAALEMEPFLPLANLHCSPDVDTFLCNAFVPACTEQIHVVPPCRKFCERVYSDCKYLIDTFGITWPEELECSRLQYCDET | ||||||
Domain | 195-502 | G-protein coupled receptors family 2 profile 2 | ||||
Sequence: LEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGNSTACNKADEKLELGETVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVGLYDLYASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQIYRIIWETTWVSDHCHRYHIPCPHQAKTLARPELALFMIKYLMTLIVGISAVFWVGSKKTCTE | ||||||
Region | 588-654 | Disordered | ||||
Sequence: EIKTSPEASVRDMGADGSSLQKARENNVGEHTSPADSSSKLSVEQVERRCKTGNSNDKSSVSGSVWS | ||||||
Compositional bias | 607-628 | Polar residues | ||||
Sequence: LQKARENNVGEHTSPADSSSKL | ||||||
Region | 669-712 | Disordered | ||||
Sequence: LLQSSNLQIPSTSQPGSPKGSTSLLIHSTLDTGKEQSSGNNSDT |
Sequence similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length712
- Mass (Da)80,150
- Last updated2019-09-18 v1
- Checksum82FE2AC9BEBD40D9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 607-628 | Polar residues | ||||
Sequence: LQKARENNVGEHTSPADSSSKL |
Keywords
- Technical term