A0A4X1UES1 · A0A4X1UES1_PIG
- ProteinRAF proto-oncogene serine/threonine-protein kinase
- GeneRAF1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids648 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | Ras protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRAF proto-oncogene serine/threonine-protein kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionA0A4X1UES1
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-131 | RBD | ||||
Sequence: NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFL | ||||||
Domain | 138-184 | Phorbol-ester/DAG-type | ||||
Sequence: THNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMC | ||||||
Region | 220-335 | Disordered | ||||
Sequence: SVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQ | ||||||
Compositional bias | 222-269 | Polar residues | ||||
Sequence: SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTT | ||||||
Compositional bias | 284-310 | Polar residues | ||||
Sequence: HSESASPSALSSSPNNLSPTGWSQPKT | ||||||
Domain | 349-609 | Protein kinase | ||||
Sequence: VMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length648
- Mass (Da)72,975
- Last updated2019-09-18 v1
- Checksum746204AAD2DE09D7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 222-269 | Polar residues | ||||
Sequence: SRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTT | ||||||
Compositional bias | 284-310 | Polar residues | ||||
Sequence: HSESASPSALSSSPNNLSPTGWSQPKT |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GACC01000347 EMBL· GenBank· DDBJ | JAA74237.1 EMBL· GenBank· DDBJ | mRNA |