A0A4W5K776 · A0A4W5K776_9TELE
- Proteinexodeoxyribonuclease III
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids256 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 18 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 44 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 116 | ||||
Active site | 144 | Proton donor/acceptor | |||
Binding site | 144 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 146 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 146 | Transition state stabilizer | |||
Site | 208 | Important for catalytic activity | |||
Binding site | 232 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 233 | Proton acceptor | |||
Binding site | 233 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 233 | Interaction with DNA substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameexodeoxyribonuclease III
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Hucho
Accessions
- Primary accessionA0A4W5K776
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5021284743 | 22-256 | exodeoxyribonuclease III | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)29,964
- Last updated2019-09-18 v1
- ChecksumA4D61CD332690FEC
Keywords
- Technical term