A0A4W5K776 · A0A4W5K776_9TELE

  • Protein
    exodeoxyribonuclease III
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

  • Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
    EC:3.1.11.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

125620406080100120140160180200220240
Type
IDPosition(s)Description
Binding site18Mg2+ 1 (UniProtKB | ChEBI)
Binding site44Mg2+ 1 (UniProtKB | ChEBI)
Active site116
Active site144Proton donor/acceptor
Binding site144Mg2+ 1 (UniProtKB | ChEBI)
Binding site146Mg2+ 1 (UniProtKB | ChEBI)
Site146Transition state stabilizer
Site208Important for catalytic activity
Binding site232Mg2+ 1 (UniProtKB | ChEBI)
Active site233Proton acceptor
Binding site233Mg2+ 1 (UniProtKB | ChEBI)
Site233Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    exodeoxyribonuclease III
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Hucho

Accessions

  • Primary accession
    A0A4W5K776

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_502128474322-256exodeoxyribonuclease III

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-233Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    29,964
  • Last updated
    2019-09-18 v1
  • Checksum
    A4D61CD332690FEC
MRIYFLLFFGMVNFMSINANGLRTMEKFESIVKMKNCDILCIQETHWDNACILEVKKIWRDFIFVNNGRGNSSGVAILLRKDVVDNVTHIYNDNNGRILVLEFEYMGMVFRIINIYAPNDEIERKDLFLDLGKWCEGKCIVVGDFNVKMDRLDMTRGAIFRSDTSRGVLKKMMFEKEVIDMWREENVDKREFSRRQVVLGELKQSRIDLVLVKEDLRDFLKDIKYVFTTFSDHAALTFSVGLDKERIGGGIWCMNA

Keywords

Genome annotation databases

Similar Proteins

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