A0A4W4HS28 · A0A4W4HS28_ELEEL
- ProteinProtein-glutamine gamma-glutamyltransferase 2
- Genetgm2b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids679 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 274 | |||||
Sequence: C | ||||||
Active site | 332 | |||||
Sequence: H | ||||||
Active site | 355 | |||||
Sequence: D | ||||||
Binding site | 395 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 397 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 443 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 448 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Molecular Function | peptidase activity | |
Molecular Function | protein-glutamine gamma-glutamyltransferase activity | |
Biological Process | nervous system development | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein-glutamine gamma-glutamyltransferase 2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0A4W4HS28
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 266-358 | Transglutaminase-like | ||||
Sequence: CMSVRYGQCWVFAAVACTVSRALGIPCRVVTNYLSAHDTNTNLVIERYYDEKGQLLNSTRDMIWNYHCWVESWMTRPDLKAGFDGWQASDPTP |
Sequence similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length679
- Mass (Da)76,360
- Last updated2019-09-18 v1
- ChecksumA2BB0E25A0B193B3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4W4HJZ3 | A0A4W4HJZ3_ELEEL | tgm2b | 706 | ||
A0A4W4HQN5 | A0A4W4HQN5_ELEEL | tgm2b | 680 | ||
A0A4W4HND4 | A0A4W4HND4_ELEEL | tgm2b | 686 | ||
A0A4W4HSP0 | A0A4W4HSP0_ELEEL | tgm2b | 598 |
Keywords
- Technical term