A0A4W4HRT2 · A0A4W4HRT2_ELEEL

Function

function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functioninsulin-like growth factor I binding
Molecular Functioninsulin-like growth factor II binding
Biological Processregulation of insulin-like growth factor receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor-binding protein 1

Gene names

    • Name
      igfbp1b

Organism names

Accessions

  • Primary accession
    A0A4W4HRT2

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond202↔222

Keywords

Interaction

Subunit

Binds equally well IGF1 and IGF2.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-112IGFBP N-terminal
Domain145-222Thyroglobulin type-1

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    228
  • Mass (Da)
    24,829
  • Last updated
    2019-09-18 v1
  • Checksum
    EF30B84C79E380EF
MIEINSQRISIAVLTSVLVPGEPSPVLAPEPIRCVPCTQEKLSGCPPVPSNCREVLKEPGCGCCLACALEQGEPCGIYTAHCGTGLRCVPRPEDPHPLHSLTRGRASFDQDSLQYLLGLNKPLDLEAHESIMAKVNAIRKKLVKLGPCHTELHSALDTIAASQQALGEKFTTFYLPNCDKHGFFKAKQCETSLVGRLMRCWCVSWNGKRIIGSSDLTADALCHQEVTH

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4HJN7A0A4W4HJN7_ELEELigfbp1b267
A0A4W4HQD1A0A4W4HQD1_ELEELigfbp1b221
A0A4W4HRT9A0A4W4HRT9_ELEELigfbp1b246
A0A4W4HSF2A0A4W4HSF2_ELEELigfbp1b252

Keywords

Genome annotation databases

Similar Proteins

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