A0A4W4GRT2 · A0A4W4GRT2_ELEEL
- ProteintRNA (cytosine(34)-C(5))-methyltransferase
- Genensun2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids702 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- cytidine48 in tRNA + S-adenosyl-L-methionine = 5-methylcytidine48 in tRNA + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- cytidine49 in tRNA + S-adenosyl-L-methionine = 5-methylcytidine49 in tRNA + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
- cytidine50 in tRNA + S-adenosyl-L-methionine = 5-methylcytidine50 in tRNA + S-adenosyl-L-homocysteine + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 182-188 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 213 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 240 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 266 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 319 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | nucleus | |
Molecular Function | tRNA (cytidine-5-)-methyltransferase activity | |
Molecular Function | tRNA binding | |
Biological Process | tRNA methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (cytosine(34)-C(5))-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0A4W4GRT2
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Compositional bias | 11-25 | Basic and acidic residues | |||
Domain | 64-426 | SAM-dependent MTase RsmB/NOP-type | |||
Region | 646-702 | Disordered | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length702
- Mass (Da)78,976
- Last updated2019-09-18 v1
- MD5 Checksum3ED374A1B2F5CCB3E1131E99953E39FC
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4W4GKR3 | A0A4W4GKR3_ELEEL | nsun2 | 758 | ||
A0A4W4GMU3 | A0A4W4GMU3_ELEEL | nsun2 | 751 | ||
A0A4W4GMP5 | A0A4W4GMP5_ELEEL | nsun2 | 735 | ||
A0A4W4GKQ4 | A0A4W4GKQ4_ELEEL | nsun2 | 698 | ||
A0A4W4GQV2 | A0A4W4GQV2_ELEEL | nsun2 | 754 | ||
A0A4W4GRR7 | A0A4W4GRR7_ELEEL | nsun2 | 754 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 11-25 | Basic and acidic residues | |||
Keywords
- Technical term