A0A4W4FHW6 · A0A4W4FHW6_ELEEL

Function

function

Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13-18ITP (UniProtKB | ChEBI)
Binding site43Mg2+ (UniProtKB | ChEBI)
Binding site55ITP (UniProtKB | ChEBI)
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site71-72ITP (UniProtKB | ChEBI)
Binding site147-150ITP (UniProtKB | ChEBI)
Binding site170ITP (UniProtKB | ChEBI)
Binding site175-176ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      itpa
    • Synonyms
      ITPA

Organism names

Accessions

  • Primary accession
    A0A4W4FHW6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,387
  • Last updated
    2019-09-18 v1
  • Checksum
    FB944621E3895A9F
MALPAGRSVVFVTGNAKKLEEVVQILGDRFPYKLVSKKIDLPEYQGEPDDISIQKCQEAAKQVEGPVIVEDTCLCFRALGGLPGPYIKWFLDKLKPEGLYRLLSGFEDKSAWALCTFAFCAGEREPVQLFRGITEGRIVEPRGPRDFGWDPCFQPDGYDKTYAELPKDVKNTISHRYRALTALSDQGVKVP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4FKQ5A0A4W4FKQ5_ELEELitpa204
A0A4W4FKE5A0A4W4FKE5_ELEELitpa203

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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