A0A4W4FGV6 · A0A4W4FGV6_ELEEL
- ProteinDihydropyrimidine dehydrogenase [NADP(+)]
- GeneDPYD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1082 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Catalytic activity
- 5,6-dihydrothymine + NADP+ = H+ + NADPH + thymineThis reaction proceeds in the backward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
Pathway
Amino-acid biosynthesis; beta-alanine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | uracil binding | |
Biological Process | beta-alanine biosynthetic process | |
Biological Process | thymine catabolic process | |
Biological Process | uracil catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropyrimidine dehydrogenase [NADP(+)]
- EC number
- Short namesDHPDHase ; DPD
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0A4W4FGV6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1040-1065 | Helical | ||||
Sequence: FFILFPVLFFFSLQLCGCLAASSVAI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-34 | |||||
Sequence: MKLLLCQKPAPFIHFLSRTLSFFLVFVSVSPDHA | ||||||
Chain | PRO_5021258235 | 35-1082 | Dihydropyrimidine dehydrogenase [NADP+] | |||
Sequence: ALCSTAAKKAEKKHWKRNSEKGCDSCVELENNFDDIKHTTLSERGALWEAMRCLKCADAPCQKSCPTDLDIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPTSDLCMGGCNLLASEEGPINIGGLQQFAIEVFNKMGIPQVRNPNLPPPEEMPDSYHSKIALIGCGPASISCASFLARLGYDNITIFEKQNYVGGLSSSEIPQFRLPYEVVQFELDLMKDLGVKVISSIKSLGQGGMTLSSLREEGYQAIFIGIGLPQANKHRIFEGLSMEQGFYTSKDFLPLVAKASKPGMCSCRSPLPQLYGRVVVLGAGDTAFDCATSALRCGARRVYVVFRRGFTNIRAVPEEMELAKEEKCEFLPFMCPKEVMLKGGRVHALEFCRTEQMDEGEWVEYPEQVIRLKADFIISAFGSGLTDQTVREAMAPIRLNRWGLPELNPETMQCSEPWVFAGGDVAGLANTTVESVNDGKQASWHIHKYLQALHEQTIGGEPQLPLFYSPVDSVDISVEVCGMTFSNPFGLASATPTTSATMIRRAFEQGWAFALTKTFSLDKDLVTNVSPRIVRGTTSGPVYGPGQGSFLNIELISEKTAAYWCQAVTELKADFPKNIIISSIMCSYTKNDWTELAKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRRAVKIPFFAKLTPSVTSIVDIARAAQEGGADGVTATNTVSGLMGLKADGSPWPAVGRDKRTTYGGVSGNAIRPIVLKAVSAIARALPAFPILATGGIDSAESGLQFLHVGASLLQVCSAVQNQDFTVIDDYCTGLKALLYLKNIEELQDWDGQSPPTARHQKGKPVPTLDALKEKRLPNFGPYLQEKKLAIAQSKQNQSNPSNIALPSNGSRINQPKKPVPAIKDVIAQALKYVGAYQELDNQDQVQALIDEEMCINCGKCYLACNDSGYQVLLVSSCPRDLTCVHACGGRHTRAHTHGKTHGPHTSSHTTPQPGATFHNLFPLHRFLAQSFFILFPVLFFFSLQLCGCLAASSVAISSCPCSQEFGAAAFACR |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 900-923 | Disordered | ||||
Sequence: AQSKQNQSNPSNIALPSNGSRINQ | ||||||
Domain | 954-983 | 4Fe-4S ferredoxin-type | ||||
Sequence: VQALIDEEMCINCGKCYLACNDSGYQVLLV |
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,082
- Mass (Da)117,678
- Last updated2019-09-18 v1
- ChecksumF9D19CB8FA03A4BE
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4W4FIT6 | A0A4W4FIT6_ELEEL | DPYD | 1020 | ||
A0A4W4FJI9 | A0A4W4FJI9_ELEEL | DPYD | 1017 | ||
A0A4W4FIY4 | A0A4W4FIY4_ELEEL | DPYD | 1026 | ||
A0A4W4FIZ4 | A0A4W4FIZ4_ELEEL | DPYD | 1017 | ||
A0A4W4FHA3 | A0A4W4FHA3_ELEEL | DPYD | 986 | ||
A0A4W4FHA7 | A0A4W4FHA7_ELEEL | DPYD | 448 |
Keywords
- Technical term