A0A4W4EU93 · A0A4W4EU93_ELEEL

Function

function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaminoacyl-tRNA synthetase multienzyme complex
Cellular Componentcytosol
Molecular Functionaspartate-tRNA ligase activity
Molecular FunctionATP binding
Molecular FunctionRNA binding
Biological Processaspartyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate--tRNA ligase, cytoplasmic
  • EC number

Gene names

    • Name
      dars1

Organism names

Accessions

  • Primary accession
    A0A4W4EU93

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-41Disordered
Compositional bias12-41Basic and acidic residues
Domain42-169Aminoacyl-transfer RNA synthetases class-II family profile

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    169
  • Mass (Da)
    19,145
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    0A9C37745A2DFC218342CB7EC2614F7B
AAGPSGRGGAEEEQAQSKKALKKQQKEAEKQAKKAENTPNEKLLGRLVKEKYDTDFYVLDKYPLEVRPFYTMPDPHNPKYSNSYDMFMRGEEILSGAQRVHDAQLLTERASHHGIDLEKIKAYIDSFRYGAPPHAGGGIGLERVTMLYLGLHNIRQTSMFPRDPKRLTP

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4EUX0A0A4W4EUX0_ELEELdars1542
A0A4W4ETU9A0A4W4ETU9_ELEELdars1520
A0A4W4EU87A0A4W4EU87_ELEELdars1518
A0A4W4EWG0A0A4W4EWG0_ELEELdars1520
A0A4W4EWF4A0A4W4EWF4_ELEELdars1530

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-41Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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