A0A4W4ETB7 · A0A4W4ETB7_ELEEL

Function

function

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.

Catalytic activity

  • Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
    EC:3.2.1.35 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

146850100150200250300350400450
TypeIDPosition(s)Description
Active site140Proton donor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentplasma membrane
Molecular Functionhyaluronoglucuronidase activity
Molecular Functionhyalurononglucosaminidase activity
Biological Processcarbohydrate metabolic process
Biological Processhyaluronan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hyaluronidase
  • EC number

Gene names

    • Name
      HYAL2

Organism names

Accessions

  • Primary accession
    A0A4W4ETB7

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_502133700726-468Hyaluronidase
Disulfide bond52↔344
Disulfide bond216↔232
Glycosylation361N-linked (GlcNAc...) asparagine
Disulfide bond369↔380
Disulfide bond374↔427
Disulfide bond429↔438

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    53,492
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    BA069BF84F1B2BEE1B87EB52087AD401
MANWFLSKWKIWVLLPLVLDYVAVAQNVKSTRWPLYPQKPLLLAWNAPTEDCGHRHGIRFQLDQFQIVASTNEGFTKQDLTIFNKDRLGLYPYFALDGTPVNGGLPQIASLSHHRERMPIGIEKYIHDPAARGLAIIDWEEWRPLWIRNWDTKNIYRNQSRLLVSKKNPTWENTQVSKVAQQEFEMSSRTFMLETLRLAKSLRPNQLWGFYLFPDCYNHNYRNSLDSYTGRCPDPEVARNDQLKWLWTESTGLFPSIYIGSVLRSTPFARQFVRNRVKEGMRVASLGEGPARPVFVYTRPTYANEMELLTETDLVSTIGESVALGAAGIILWGDASYTRSNASCSSLDQYLRGPLGRYLLNVSTAAEQCSRSACSAQGRCLRRRPDTDTYLHLNPRSYTIVAQESQLAVRGHMGAEELKSMKEDFVCQCFSGYQGDSCELQDPLQQKGRGNRRQAALLFCLLPLLLTV

Keywords

Genome annotation databases

Similar Proteins

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