A0A4W4EN95 · A0A4W4EN95_ELEEL

Function

function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionhistone binding
Molecular Functionmetal ion binding
Molecular Functionubiquitin protein ligase activity
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase UHRF
  • EC number
  • Alternative names
    • RING-type E3 ubiquitin transferase UHRF
    • Ubiquitin-like PHD and RING finger domain-containing protein
    • Ubiquitin-like-containing PHD and RING finger domains protein

Gene names

    • Name
      uhrf1

Organism names

Accessions

  • Primary accession
    A0A4W4EN95

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-78Ubiquitin-like
Region76-124Disordered
Compositional bias94-123Polar residues
Domain310-377PHD-type
Domain329-375RING-type
Domain430-593YDG
Region620-646Disordered
Compositional bias621-646Basic and acidic residues
Domain694-733RING-type

Domain

The YDG domain mediates the interaction with histone H3.
The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    763
  • Mass (Da)
    85,836
  • Last updated
    2019-09-18 v1
  • Checksum
    0CAA970C477B1F43
MWIQVRTMDGKQTHRVDSLSKLTKVDDLRVKILELFDVEPERQRLFYRGKQMEDGHTLFDYNVGLNDIVQLLVRQAPPPRPLPKDKEGELSDSDSGCGSGQSDSDKSSTHGECEGQSAGTSAQADLIDPGFGSYKINEFVDARDLNMGAWFEAQIVDVTKAPKTDGGGGVSSRPVIVWISELARAPLESDCVCVSVRSYPENGVAQLQAKDVRPRARTIYQWHQLEEGMIVMVNYNPDEPKERGYWYDAQVQRKRETRTQREIFGKLLDAGDSLNDCRIMFVSEIYKIEEPGSREGPVATSDSPLKRSNGPECKLCKDDPKKNCRWCNCRVCGVKQDPDKQLLCDECDMAFHTYCLTPPLTSIPEDEDWYCPECRNDASEVVLAGEKLKESKKKAKMASASSSSQRDWGKGMACVGRTKQCTIVPSNHYGPVPGVPVGTLWKFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDDGNEFTYTGSGGRDLSGNKRTAEQSCDQKLTNMNRALALNCNAAVNEKDGAEARDWKAGKPVRVVRSSKGRKHSKYCPEDGNRYDGIYKVVKYWPEKGKSGFLVWRYLLKRNDDEPAPWTRDGKERIKKLGLTMQVMPAAKEKEKENKNEEEKRSPSKSTPKKVKMEAYKLNKEQKALIKEDELNKKLWDEAMESLSLGPRFLNKVEEVFLCICCQEVVYQPVTTECQHNVCRECLQRSFKAEVYTCPACRHDLGKNYQMVVNKALQAILSQLFPGYSSGR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4EPD8A0A4W4EPD8_ELEELuhrf1784
A0A4W4ELA1A0A4W4ELA1_ELEELuhrf1772
A0A4W4EPE2A0A4W4EPE2_ELEELuhrf1750

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias94-123Polar residues
Compositional bias621-646Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

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