A0A4W4EFY7 · A0A4W4EFY7_ELEEL
- ProteinAngiotensin-converting enzyme
- Geneace2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids782 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- angiotensin I + H2O = angiotensin-(1-9) + L-leucineThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 375 | Proton acceptor 1 | |||
Active site | 375 | Proton acceptor 2 | |||
Active site | 505 | Proton donor 1 | |||
Active site | 505 | Proton donor 2 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0A4W4EFY7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 750-771 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5021461309 | 21-782 | Angiotensin-converting enzyme | ||
Glycosylation | 55 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 132↔140 | ||||
Disulfide bond | 343↔361 | ||||
Disulfide bond | 530↔542 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length782
- Mass (Da)90,066
- Last updated2019-09-18 v1
- MD5 Checksum71731BDCFA0545940E4E95D184013930
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4W4EE33 | A0A4W4EE33_ELEEL | ace2 | 780 |
Keywords
- Technical term