A0A4W4E6F7 · A0A4W4E6F7_ELEEL

Function

Catalytic activity

  • (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • octadecanoyl-CoA + O2 = (2E)-octadecenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • octanoyl-CoA + O2 = (2E)-octenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • tetradecanoyl-CoA + O2 = (2E)-tetradecenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2
    This reaction proceeds in the forward direction.
  • hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site139FAD (UniProtKB | ChEBI)
Binding site178FAD (UniProtKB | ChEBI)
Active site421Proton acceptor

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular FunctionFAD binding
Molecular Functionfatty acid binding
Molecular Functionpalmitoyl-CoA oxidase activity
Biological Processfatty acid beta-oxidation using acyl-CoA oxidase
Biological Processlipid homeostasis
Biological Processvery long-chain fatty acid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-coenzyme A oxidase

Gene names

    • Name
      acox1

Organism names

Accessions

  • Primary accession
    A0A4W4E6F7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-133Acyl-coenzyme A oxidase N-terminal
Domain136-245Acyl-CoA oxidase/dehydrogenase middle
Domain275-436Acyl-CoA oxidase C-alpha1
Domain491-660Acyl-CoA oxidase C-terminal

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    664
  • Mass (Da)
    74,244
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    B5051154E958316D76CC1D0813521A02
MNPDICTERGNATFNPEVLTNILDGGAEKTRRRREIEALVISDPDFQHEDLNFLSRTERYDAALKKSALMFLKLRNYGISNPEEIYCYKSCVHRGRSQPLDLHLGMFLPTLLNQASPAQLDVFFTPAWNLEIIGTYAQTELGHGTHIRRLETTATYDPSTQEFVLNSPTVTSIKWWPGGLGKTSNHAIVLAQLYTQGQCHGLHGFIVPIRCMKTHQPLPGVVVGDIGPKFGFDEVDNGYLKLENVRIPRENMLMKYAKVEPDGTYLKPPSDKLTYGTMVFIRAMIVGESARALSKACTIAIRYSAVRHQSELQPGEAEPQILDYQAQQYKLFPLLATAYAFTFVGQYMSQMYNRITGDINQGDFSELPELHALAAGLKAFTTWTANAGIEVCRMACGGHGYSRCSSLPDIYVTFTATCTYEGENTVMMLQMARYLVKSYRQAKEGQQLTGIVSYLNEPQQRVQTRPASSRPAVVDINDLASLVEHPPGAADVNLVRLVEVAAKSLQGELQRSKHREDPWNNSSIELIRASEAHCHYVVVKLFAAKLTEISDTAVHSALSSLALLYALHGVANNSGDFLQADLLSVPQLSQVTQRMKALLAEIRLNAVALVDAFDYHDEMLNSVLGRYDGNVYESMFEWAKRSPLNRTEVHESYNKYLKPLQSKL

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4E6Q7A0A4W4E6Q7_ELEELacox1668
A0A4W4E7V8A0A4W4E7V8_ELEELacox1663
A0A4W4E7T4A0A4W4E7T4_ELEELacox1665
A0A4W4E8Y7A0A4W4E8Y7_ELEELacox1668

Keywords

Genome annotation databases

Similar Proteins

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