A0A4W4DWQ9 · A0A4W4DWQ9_ELEEL

Function

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Molecular Functionbroad specificity oxidative DNA demethylase activity
Molecular Functionferrous iron binding
Molecular FunctionmRNA N6-methyladenosine dioxygenase activity
Biological ProcessDNA alkylation repair
Biological Processregulation of multicellular organism growth
Biological ProcessRNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-ketoglutarate-dependent dioxygenase FTO
  • EC number
  • Alternative names
    • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    • mRNA N(6)-methyladenosine demethylase FTO
    • tRNA N1-methyl adenine demethylase FTO

Gene names

    • Name
      FTO

Organism names

Accessions

  • Primary accession
    A0A4W4DWQ9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer. May also exist as homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain35-299Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Region125-174Disordered
Compositional bias136-153Basic and acidic residues
Compositional bias156-174Polar residues

Sequence similarities

Belongs to the fto family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    55,592
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    450CE174BB5FEC43243AA00AA8A56457
GGGTAGEGSDKRGGQRRRLLQELGEQRIPFLSPSDAGFQQLWESSYAGLTVRKAGALPGDLHERVQSALSTLLQRGCLLRDLVRVRDRDVFTAVSRALVGQPGCTYRYLDTRLFTIPWHCGDGDESCPPATPTXAEDRVLEEKEQRAEKEEVGGDSNSGQGCSQALDPPTATPSRPVQFNITLINYMDPRGMTQLKQEPYYGMGKMAVGWHHDENLVPLSPLAVYSYSCPGETKTEETEEACWRVGLKVAWDIHTPGLALPLQSGDCYYMTDDLNRTHQHCVLAGETARFSSTHRVAQCSTGTLEYIQRRCSEALENLHTDPESGAKSLRSLILSTLQHIEDIHNEVEFEWLRQYWFQGRRYARFCSWWSKPMERLEADWKQMERMTELLLALVEDESSVQENRREMAETLLNALTDRQQHRQTWRDRCQSNLAQTLPPEEAPIDRPYWSGDDPDMPLPFDLSDIISRTPTWNGWTGERLARLMCIVGKT

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4DY90A0A4W4DY90_ELEELFTO480
A0A4W4DY84A0A4W4DY84_ELEELFTO484
A0A4W4DWF7A0A4W4DWF7_ELEELFTO413
A0A4W4DX10A0A4W4DX10_ELEELFTO484
A0A4W4DX14A0A4W4DX14_ELEELFTO419

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias136-153Basic and acidic residues
Compositional bias156-174Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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