A0A4W4DWQ9 · A0A4W4DWQ9_ELEEL
- ProteinAlpha-ketoglutarate-dependent dioxygenase FTO
- GeneFTO
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- N6-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2
- an N1-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Molecular Function | broad specificity oxidative DNA demethylase activity | |
Molecular Function | ferrous iron binding | |
Molecular Function | mRNA N6-methyladenosine dioxygenase activity | |
Biological Process | DNA alkylation repair | |
Biological Process | regulation of multicellular organism growth | |
Biological Process | RNA repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-ketoglutarate-dependent dioxygenase FTO
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0A4W4DWQ9
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 35-299 | Alpha-ketoglutarate-dependent dioxygenase FTO catalytic | |||
Region | 125-174 | Disordered | |||
Compositional bias | 136-153 | Basic and acidic residues | |||
Compositional bias | 156-174 | Polar residues | |||
Sequence similarities
Belongs to the fto family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)55,592
- Last updated2019-09-18 v1
- MD5 Checksum450CE174BB5FEC43243AA00AA8A56457
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A4W4DY90 | A0A4W4DY90_ELEEL | FTO | 480 | ||
A0A4W4DY84 | A0A4W4DY84_ELEEL | FTO | 484 | ||
A0A4W4DWF7 | A0A4W4DWF7_ELEEL | FTO | 413 | ||
A0A4W4DX10 | A0A4W4DX10_ELEEL | FTO | 484 | ||
A0A4W4DX14 | A0A4W4DX14_ELEEL | FTO | 419 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 136-153 | Basic and acidic residues | |||
Compositional bias | 156-174 | Polar residues | |||
Keywords
- Technical term