A0A4W4DPH5 · A0A4W4DPH5_ELEEL

Function

function

Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentER to Golgi transport vesicle membrane
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionprotein dimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processpositive regulation of cholesterol storage
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sterol regulatory element-binding protein 2
  • Alternative names
    • Sterol regulatory element-binding transcription factor 2

Gene names

    • Name
      srebf2

Organism names

Accessions

  • Primary accession
    A0A4W4DPH5

Proteomes

Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Nucleus

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain276-326BHLH
Region357-376Disordered

Sequence similarities

Belongs to the SREBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,049
  • Mass (Da)
    115,078
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    BAE0CF0C0FC00F7E640567E498874D07
MDSGDYLSTMDPTLSELGDEFTLGDIDEMLQFVSNQPDFPDLFEEQMGCGSLQSGVGGPTLAMSSPAFPVQTQTLALQAHTHTQAQTVMLTPTATQSRFIQNPVICHQSTSSVLQPQVQSIVTSPQVQPLTIQHQRVLTPAGQTIQTLSTAPTAVHTVSPQVHQVPVLVHQPQILKTDSLVLTTLKPDGTQVLSTMQNPGGITTLTTPLQSTALQVPTLVGSNILTTVPVVMGSNDKLPIKQLPSAPAHSGGMARTVVEQSTAVAVGTGGPLKEGERRTTHNIIEKRYRSSINDKILELRDLVMGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLELKMKKHKCVVDEVDMKAESVMTPPPSDSGSASPPEFSPFCIDSEPGSPLLENEQLKSEPGSPSSVGVMDRSRVLLCALTFLCLSLNPLPSLLGSDERSTPYWPSGEGHGPSRSLVWLPAQTQSFASWLWLVLPWVTVWVLSGVGVVWGCVRVLYLWEPVTPLHSPTSVLFWRHRRQGDYCTAVVSLETCLSVLSRALPTTTLDLACSISWNLIRYCLYRPTPLGWLVRLVAGKHEGEESQTSSRDAALVYHKLGQLQLTGKLSERSAAWAVCVCLNAVNLSESARGKMSPTEHAHIYISAAIALRTALTNHLTCLSGYLLSCAESLVCQSDSKPLPDNLRWLFTPLGRQFFLSCDWSVKPKSSEGVYTSERNQVDPVAQLHRCFCEKLLERAVHTLIQPHSDTETPKRRDETGEFSGVLEFLQLLNSCTEDSASPTPPFPALANENPVSDPVCRWWASVLKAAVHWLQGDDTAVRSLLAEAERMPRALHSLDHPLPKAMLALCKAVQMSVCPQKDEGTLSCYTHCERASTLLHNSISHTHTYTWLHKGVQLLICDLLLTLRTSLWQRGNGSNAEPGPAPGSQLAGFQRDLSSLRKLGQGNPQIQHKVFLHETTVRLMAGASPTRTHQLLEHSLRRRTHAHTEGVCVAGERERAHAILLACRHLPLPLLSPPGHPARMLDEAKRTLERVGDHRTLHDCQHVLLRGTALAAS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W4DNM8A0A4W4DNM8_ELEELsrebf21080

Keywords

Genome annotation databases

Similar Proteins

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