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A0A4W3K135 · A0A4W3K135_CALMI

Function

function

Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentprotein phosphatase type 1 complex
Molecular Functionprotein phosphatase regulator activity
Biological Processpositive regulation of phosphoprotein phosphatase activity
Biological Processresponse to endoplasmic reticulum stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein DP71L
  • Alternative names
    • MyD116 homolog

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Holocephali > Chimaeriformes > Callorhinchidae > Callorhinchus

Accessions

  • Primary accession
    A0A4W3K135

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_502145414116-547Protein DP71L

Expression

Keywords

Interaction

Subunit

Interacts (via C-terminus) with host PPP1CB.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region13-43Disordered
Region124-155Disordered
Region276-350Disordered
Domain314-423Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Compositional bias317-341Acidic residues
Region384-406Disordered
Compositional bias392-406Polar residues
Domain451-543Protein phosphatase 1 regulatory subunit 15A/B C-terminal

Sequence similarities

Belongs to the PPP1R15 family.
Belongs to the asfivirus DP71L family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    59,815
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    AC975BD73244EDAE6CD16EDACB2BD105
MLRLLSAFFPRPSLALSHTGPGPEPRAPDETGSKAGEAAEAQASTGVFSGGLVSSVLHWLKPPEQGLVPGPAAAELSLYRDAAPEEAPRPLLHSAESPGVGSSPPPVFPAPGVLQTLWDKLAGGAPEPPFRSGSWRSAAVSPPGPCGRPGGGSGLHVQTKADTRGSELLLPDVGIKEKSAELFHHVRDLCVVTPEQDYGYSSLEEEHNYAQHRGVYSCRSGETEAASEDNCSKSAGDSETCEVVVADHEFVLQGSVDLTMTSDSFEASDGKLSIGYDEWDSDSESEDAANEEANSPSIPRPRCSNKTIAYILGGNSSDEESEDEEDKASDWDDDGFDSETSSDFSDSDCSSDETEKLWNSFSSSWDPYNPLNFQACIKTTKRQKKTLPENPELHQETTSGSTCPQQSLSSLVDSDTAMDSGFSEAVQNQLFFQFADILYSRCGIATICSKCRVHWFGSRASGCLLVSVIRLYFPQRETCLLFVIVAFDEHVIEYYVSSEEIRKGPWEEYARDRCRFQRRIRETEESIGYCFTFEHRQSVLERLLMDS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W3J3F4A0A4W3J3F4_CALMI528
A0A4W3J699A0A4W3J699_CALMI505

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias317-341Acidic residues
Compositional bias392-406Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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