A0A4W3HTX4 · A0A4W3HTX4_CALMI

Function

function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • (9Z)-hexadecenoyl-CoA + H+ + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z)-octadecenoyl-CoA + H+ + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + H+ + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z,15Z)-octadecatrienoyl-CoA + H+ + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • H+ + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • H+ + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.
  • a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
    EC:2.3.1.199 (UniProtKB | ENZYME | Rhea)
  • dodecanoyl-CoA + H+ + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism; fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid elongase activity
Biological Processfatty acid elongation, monounsaturated fatty acid
Biological Processfatty acid elongation, polyunsaturated fatty acid
Biological Processfatty acid elongation, saturated fatty acid
Biological Processlong-chain fatty-acyl-CoA biosynthetic process
Biological Processsphingolipid biosynthetic process
Biological Processunsaturated fatty acid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation of very long chain fatty acids protein 6
  • EC number
  • Alternative names
    • 3-keto acyl-CoA synthase ELOVL6
    • ELOVL fatty acid elongase 6
      (ELOVL FA elongase 6
      )
    • Very long chain 3-ketoacyl-CoA synthase 6
    • Very long chain 3-oxoacyl-CoA synthase 6

Gene names

    • Name
      ELOVL6
    • Synonyms
      LOC103182716

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Holocephali > Chimaeriformes > Callorhinchidae > Callorhinchus

Accessions

  • Primary accession
    A0A4W3HTX4

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-51Helical
Transmembrane63-86Helical
Transmembrane162-183Helical
Transmembrane195-220Helical
Transmembrane232-251Helical

Keywords

PTM/Processing

Post-translational modification

N-Glycosylated.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ELO family. ELOVL6 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    31,737
  • Last updated
    2019-09-18 v1
  • Checksum
    6F898ABDB79EA47C
MNMSVIALQEYEFEKQFDERGAMEWMQENWSKSFLFSAVYAGLIFAGQYYMRERTKFELRKPLMLWSLMLALFSILGAFRTGWYMWHVFYTGGFKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTLFIVLRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAFMYSYYTLRAAGFHVPRRFAMLITLTQITQMVMGMVVNILVYMWMHEGHCRSYIENIILSSIMYFSYFLLFCYFFYETYLNRKKHTKVE

Keywords

Genome annotation databases

Similar Proteins

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