A0A4W2IDU3 · A0A4W2IDU3_BOBOX

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaggresome
Cellular Componentcell cortex
Cellular Componentcentrosome
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentgamma-secretase complex
Cellular Componentglutamatergic synapse
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentkinetochore
Cellular Componentmembrane raft
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Cellular Componentnuclear outer membrane
Cellular Componentnucleoplasm
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentrough endoplasmic reticulum
Cellular Componentsmooth endoplasmic reticulum
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Molecular FunctionATPase binding
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium channel activity
Molecular Functiongrowth factor receptor binding
Molecular FunctionPDZ domain binding
Biological Processamyloid-beta formation
Biological Processapoptotic signaling pathway
Biological Processastrocyte activation involved in immune response
Biological Processautophagosome assembly
Biological Processblood vessel development
Biological Processbrain morphogenesis
Biological ProcessCajal-Retzius cell differentiation
Biological Processcell fate specification
Biological Processcell-cell adhesion
Biological Processcellular response to amyloid-beta
Biological Processcerebral cortex cell migration
Biological Processcholine transport
Biological ProcessDNA damage response
Biological Processdorsal/ventral neural tube patterning
Biological Processembryonic limb morphogenesis
Biological Processepithelial cell proliferation
Biological Processheart looping
Biological Processhematopoietic progenitor cell differentiation
Biological Processintracellular signal transduction
Biological ProcessL-glutamate import across plasma membrane
Biological Processlocomotion
Biological Processmembrane protein ectodomain proteolysis
Biological Processmemory
Biological Processmitochondrial transport
Biological Processmyeloid dendritic cell differentiation
Biological Processnegative regulation of apoptotic signaling pathway
Biological Processnegative regulation of axonogenesis
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of protein phosphorylation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of ubiquitin-dependent protein catabolic process
Biological Processneuron apoptotic process
Biological Processneuron cellular homeostasis
Biological Processneuron development
Biological Processneuron migration
Biological Processneuron projection maintenance
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of amyloid fibril formation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of coagulation
Biological Processpositive regulation of dendritic spine development
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of glycolytic process
Biological Processpositive regulation of L-glutamate import across plasma membrane
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of protein phosphorylation
Biological Processpositive regulation of receptor recycling
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpost-embryonic development
Biological Processprotein catabolic process at postsynapse
Biological Processprotein glycosylation
Biological Processprotein processing
Biological Processprotein transport
Biological Processregulation of canonical Wnt signaling pathway
Biological Processregulation of postsynapse organization
Biological Processregulation of resting membrane potential
Biological Processregulation of synaptic plasticity
Biological Processregulation of synaptic transmission, glutamatergic
Biological Processregulation of synaptic vesicle cycle
Biological Processresponse to oxidative stress
Biological Processsequestering of calcium ion
Biological Processskeletal system morphogenesis
Biological Processskin morphogenesis
Biological Processsmooth endoplasmic reticulum calcium ion homeostasis
Biological Processsomitogenesis
Biological Processsynapse organization
Biological Processsynaptic vesicle targeting
Biological ProcessT cell activation involved in immune response
Biological ProcessT cell receptor signaling pathway
Biological Processthymus development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • Name
      PSEN1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A4W2IDU3

Proteomes

Subcellular Location

Cell projection, axon
Cytoplasmic granule
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Synapse

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-97Helical
Transmembrane130-151Helical
Transmembrane158-180Helical
Transmembrane192-210Helical
Transmembrane222-238Helical
Transmembrane244-260Helical
Transmembrane415-435Helical
Transmembrane441-460Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-22Polar residues
Region1-64Disordered
Compositional bias23-45Basic and acidic residues
Region303-343Disordered
Compositional bias305-332Polar residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    53,183
  • Last updated
    2019-09-18 v1
  • Checksum
    81C970E23C0A8797
MTELPAPLSYFQNAQMSEDNHLSNTNDSRERHEHGNERRRRGNTESVSNGRAPSSSQQVVEQEEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVAQRALHSILNAVIMISVIVIMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAMDYISVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVSKNSNYNAQRPANSPVTTTGTESESQDPVTESDDGGFSEEWEAQRDSRLGPHHSTAESRSAVQDLSSSILASEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPVSITFGLIFYFATDYLVQPFMDQLAFHQFYI

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W2D2P2A0A4W2D2P2_BOBOXPSEN1468
A0A4W2ES48A0A4W2ES48_BOBOXPSEN1410
A0A4W2ERK8A0A4W2ERK8_BOBOXPSEN1468
A0A4W2ERL1A0A4W2ERL1_BOBOXPSEN1478
A0A4W2D2N8A0A4W2D2N8_BOBOXPSEN1180

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-22Polar residues
Compositional bias23-45Basic and acidic residues
Compositional bias305-332Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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