A0A4W2I0B7 · A0A4W2I0B7_BOBOX

Function

function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentearly endosome
Cellular ComponentGolgi apparatus
Cellular Componentneuronal dense core vesicle
Cellular Componentnucleus
Cellular Componentreceptor complex
Molecular Functionadenylate cyclase binding
Molecular Functionamyloid-beta binding
Molecular Functionbeta2-adrenergic receptor activity
Molecular Functionnorepinephrine binding
Molecular Functionpotassium channel regulator activity
Molecular Functionprotein homodimerization activity
Molecular Functionprotein-containing complex binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processbone resorption
Biological Processbrown fat cell differentiation
Biological Processcellular response to amyloid-beta
Biological Processdiet induced thermogenesis
Biological Processheat generation
Biological Processnegative regulation of multicellular organism growth
Biological Processnegative regulation of smooth muscle contraction
Biological Processnorepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
Biological Processpositive regulation of autophagosome maturation
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of lipophagy
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of mini excitatory postsynaptic potential
Biological Processpositive regulation of protein kinase A signaling
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processreceptor-mediated endocytosis
Biological Processregulation of sodium ion transport
Biological Processresponse to cold
Biological Processsmooth muscle contraction
Biological Processtranscription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Beta-2 adrenergic receptor
  • Short names
    Beta-2 adrenoceptor
  • Alternative names
    • Beta-2 adrenoreceptor

Gene names

    • Name
      ADRB2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A4W2I0B7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Early endosome
Golgi apparatus
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane31-58Helical
Transmembrane70-96Helical
Transmembrane108-129Helical
Transmembrane150-169Helical
Transmembrane199-219Helical
Transmembrane275-295Helical
Transmembrane307-327Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain50-326G-protein coupled receptors family 1 profile
Region398-418Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    418
  • Mass (Da)
    47,136
  • Last updated
    2019-09-18 v1
  • Checksum
    CAB2A18465722B99
MGQPGNRSVFLLAPNASHAPDQNVTLERDEAWVVGMGILMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGACHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYLAITSPFKYQCLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRASHKEAINCYAKETCCDFFTNQPYAIASSIVSFYLPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNVSQVEQDGRSGLGQRRTSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIKDNLIRKEIYILLNWLGYINSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGCSSNSNDRTDYTGEQSGYHLGEEKDSELLCEDPPGTENFVNQQGIVPSDSTDSQGRNCSTNDSLL

Genome annotation databases

Similar Proteins

Disclaimer

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