A0A4W2GEW6 · A0A4W2GEW6_BOBOX
- Proteinprotein-tyrosine-phosphatase
- GenePTPRJ
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1232 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameprotein-tyrosine-phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A4W2GEW6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 871-891 | Helical | ||||
Sequence: AVFGCIFGALVIVAVGGFIFW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-35 | |||||
Sequence: MKPAAREARPPPRSPGLRWALPPLLLLLRLGQILC | ||||||
Chain | PRO_5021350869 | 36-1232 | protein-tyrosine-phosphatase | |||
Sequence: ADNCKSSPVKAVTTSPSSVTATWKNSTTASDSMGGIKSTNENLHTAANQTGYNSMDSGPGGNGTSGDTAVEPHPVMDLRAAFVGVTHVTLTWKTDNITSTCRMLLEGSQELTTNLTVNIFRLKPGSQYTVTLYPLGLNETQGSPLSTENGLDAGNTDSLPGGPTAPGSKYRLERAGPSSDASLAPDTVEVLLLRLKPGTQYKATVYPQAVKGAEGQPQATEFKTNSSQVFDIKFVNISATSLTMTWKINDNESSSVYTYKIQVVDETDSFNLTVNETHAVITELSSGTLYNITVYPVLEDGSEGTPGFIQVYTPPSPVSDFRVTSVSTREVGLAWNSNDTHSFEIHITPHEAGEPRIITTTEQSIVFGGLYPGTMYRFDIYPQGPNGTKGDSQTVSTTTDCSAVFDIRVINVTTTDMQLAWQNTDNTSEYIYSVEIQSEHSSDRKNSSHTGIAFHDLTPGTLYKITVTPQMDFVQGLANSTLQYTRPSKVSSIEIMTNTTAATLNWQNVDEASSNYTYCLLIRQDGSSSNFPPIVTDVGVTHATVTNLIPGSSYTVEIFTKMGDVKSLGPSRQSFCTDPESVASFDCEAVPKKATLVLRWACPLGTSTGFELEVSHGYWKNKTTLEGCSLNNGSEFMTEVTHLNFSTLYDISIATHSCNKTAPPAQNTCLSGITDPPLPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYALVLTTVDADRPSADVLRFTYGDFKRGASNTYVTYLITTEAKRRAQGLSEVLKYEVDVGNESTTHGYYNGKLEPLGSYRACVAGFTNIAFNPRNAGLIDGNESYVSFSPCSEAVFLPQDPGVICGAVFGCIFGALVIVAVGGFIFWRRRRKGVKNNDVTFSQIKPKKSKLIKVENFEAYFKKQQADSNCGFAEEYEDLKLVGINLPKYAAELAENRGKNRYNNVLPYDVSRVKLSVQTHSTDDYINANYMPGYHSKEDFIATQGPLPNTLKDFWRMVWEKNVYAVVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNTPTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFVAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRSQKDSKVDLIYQNTTAMTIYENLSPITTFGKTNGYIA |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 52-99 | Polar residues | ||||
Sequence: SSVTATWKNSTTASDSMGGIKSTNENLHTAANQTGYNSMDSGPGGNGT | ||||||
Region | 52-103 | Disordered | ||||
Sequence: SSVTATWKNSTTASDSMGGIKSTNENLHTAANQTGYNSMDSGPGGNGTSGDT | ||||||
Region | 176-202 | Disordered | ||||
Sequence: QGSPLSTENGLDAGNTDSLPGGPTAPG | ||||||
Domain | 263-352 | Fibronectin type-III | ||||
Sequence: QVFDIKFVNISATSLTMTWKINDNESSSVYTYKIQVVDETDSFNLTVNETHAVITELSSGTLYNITVYPVLEDGSEGTPGFIQVYTPPSP | ||||||
Domain | 521-616 | Fibronectin type-III | ||||
Sequence: RPSKVSSIEIMTNTTAATLNWQNVDEASSNYTYCLLIRQDGSSSNFPPIVTDVGVTHATVTNLIPGSSYTVEIFTKMGDVKSLGPSRQSFCTDPES | ||||||
Domain | 936-1193 | Tyrosine-protein phosphatase | ||||
Sequence: FAEEYEDLKLVGINLPKYAAELAENRGKNRYNNVLPYDVSRVKLSVQTHSTDDYINANYMPGYHSKEDFIATQGPLPNTLKDFWRMVWEKNVYAVVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNTPTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFVAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI | ||||||
Domain | 1111-1184 | Tyrosine specific protein phosphatases | ||||
Sequence: INFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFVAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYV |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,232
- Mass (Da)135,483
- Last updated2019-09-18 v1
- Checksum56EFDC7B06F55224
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 52-99 | Polar residues | ||||
Sequence: SSVTATWKNSTTASDSMGGIKSTNENLHTAANQTGYNSMDSGPGGNGT |