A0A4W2GES7 · A0A4W2GES7_BOBOX

Function

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site185substrate
Active site219Phosphocysteine intermediate
Binding site219-225substrate
Binding site266substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic side of endoplasmic reticulum membrane
Cellular Componentearly endosome
Cellular Componentendosome lumen
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Cellular Componentsorting endosome
Molecular Functionephrin receptor binding
Molecular Functionprotein tyrosine phosphatase activity
Molecular Functionreceptor tyrosine kinase binding
Molecular Functionzinc ion binding
Biological Processactin cytoskeleton organization
Biological Processinsulin receptor recycling
Biological Processinsulin receptor signaling pathway
Biological ProcessIRE1-mediated unfolded protein response
Biological Processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of PERK-mediated unfolded protein response
Biological Processnegative regulation of vascular endothelial growth factor receptor signaling pathway
Biological Processplatelet-derived growth factor receptor-beta signaling pathway
Biological Processpositive regulation of receptor catabolic process
Biological Processregulation of endocytosis
Biological Processregulation of hepatocyte growth factor receptor signaling pathway
Biological Processregulation of intracellular protein transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type
  • EC number

Gene names

    • Name
      PTPN1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A4W2GES7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane406-424Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-26Disordered
Domain35-281Tyrosine-protein phosphatase
Domain193-272Tyrosine specific protein phosphatases
Region295-375Disordered
Compositional bias320-342Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    429
  • Mass (Da)
    49,194
  • Last updated
    2019-09-18 v1
  • Checksum
    8C19EFE0A5CBD783
MTDSSGISQSAAYEPREKRGASCEQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEREMVFEDTNLKLTLISEDIKSYYTVRQLELENLMSRETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSREHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQEQWKELSHEDLEPPPEHVPPPPRPPKRVLEPHNGKCKEFFPNHQWVKDDTEEEDKEDGPVQEATRAPLNAPCSLESASQDTEVRRRVVGADPAQGEPSLPAEERDQPLSHWKPFLVNVCVATVLTAGAYLCYRVCFH

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W2I309A0A4W2I309_BOBOXPTPN1425
A0A4W2HY51A0A4W2HY51_BOBOXPTPN1429

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias320-342Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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