A0A4W2ERL1 · A0A4W2ERL1_BOBOX

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological Processamyloid precursor protein catabolic process
Biological Processapoptotic process
Biological Processcell adhesion
Biological Processintracellular signal transduction
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • Name
      PSEN1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A4W2ERL1

Proteomes

Subcellular Location

Cell projection, axon
Cytoplasmic granule
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Synapse

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane83-101Helical
Transmembrane134-155Helical
Transmembrane162-184Helical
Transmembrane196-214Helical
Transmembrane226-242Helical
Transmembrane248-264Helical
Transmembrane419-439Helical
Transmembrane445-464Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-27Polar residues
Region1-68Disordered
Compositional bias28-49Basic and acidic residues
Region307-347Disordered
Compositional bias309-336Polar residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    53,654
  • Last updated
    2019-09-18 v1
  • Checksum
    59E3FC0A1010D906
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDSRERHEHGNERRRRGNTESVSNGRAPSSSQQVVEQEEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVAQRALHSILNAVIMISVIVIMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAMDYISVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVSKNSNYNAQRPANSPVTTTGTESESQDPVTESDDGGFSEEWEAQRDSRLGPHHSTAESRSAVQDLSSSILASEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPVSITFGLIFYFATDYLVQPFMDQLAFHQFYI

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A4W2D2P2A0A4W2D2P2_BOBOXPSEN1468
A0A4W2ES48A0A4W2ES48_BOBOXPSEN1410
A0A4W2ERK8A0A4W2ERK8_BOBOXPSEN1468
A0A4W2D2N8A0A4W2D2N8_BOBOXPSEN1180
A0A4W2IDU3A0A4W2IDU3_BOBOXPSEN1474

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-27Polar residues
Compositional bias28-49Basic and acidic residues
Compositional bias309-336Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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