A0A4V0YX64 · A0A4V0YX64_MEGAM
- Proteinnon-specific serine/threonine protein kinase
- GeneIRE1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1031 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | IRE1-TRAF2-ASK1 complex | |
Molecular Function | ATP binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | RNA endonuclease activity | |
Molecular Function | unfolded protein binding | |
Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | IRE1-mediated unfolded protein response | |
Biological Process | mRNA processing | |
Biological Process | regulation of gene expression | |
Biological Process | regulation of primary metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Xenocyprididae > Xenocypridinae > Megalobrama
Accessions
- Primary accessionA0A4V0YX64
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MMAWGVCSRALVWIITA | ||||||
Chain | PRO_5020202783 | 18-1031 | non-specific serine/threonine protein kinase | |||
Sequence: VMWWSHSSLMGFCSSSTVSVPESLLFVSTLDGNLHAVSKRSGTIKWTLKEDPVLQVPTHVSEPAFLPDPNDGSLYSLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDVWYVVDLLTGEKQQTLTSSYAEMLCPSSSLLYLGRTEYTITMYDTKSRELRWNATYSDYAFTLPDDDTKYNMAHFVSNGDGLVVTVDSESGDVQWVQNYNSPVVAIYIWQREGLRKVPHTNVAVETLRYLTFMSGEVGRITQWKYPFPREKKTKDKLMSTLYVGKHSTGLYASPSLVHDGVTVVPRGRTFPMLEGPSNQESSVEDEQECVITPSTTVKFSAALKERNRMNVMRNSLLLIGHHETPPDAHNKILEKFPESIPRQHVNIIPPATEKTIEEKVNESGMEDNSPLPPPVSSLQEKPGRLPRVETPVDSMLKDMATIIFCTFLLAGWVAFIITYPKSVHKQQQLQHQQFQQQMEEKLQLLQRQQLIFQPPTDLPPDTDFLEAARTRSESSGHSSPNVTPRASNHSNMSQSEMGHSANEHEDTEDESNIVRIGNITFSPRDVLGHGAEGTIVYRGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCSSTLQEYVERKDFDRHGLEPVTLLEQTMSGLSHLHSLNIVHRDLKPHNILVSMPNTHGRVKAMISDFGLCKKLAVGRHSFSRKSGVPGTEGWIAPEVLSEDAKHNPTCMVDIFSAGCVFYYVVSEGQHPFGKSLQRQANILLGAYSLDHLQPNRHEDIVARNLIEQMLSMEPEKRPSADRVLKHPFFWSLEKQLQFFQDVSDRIEKEPLDGPIVRQLERGGRVVVKGDWRDHITVPLQTDLRRFRSYKGGSVRDLLRAMRNKKHHYRELPDEVQETLGSIPDEFVSYFTSRFPLLLQHTHLAMRFCAAERPFLPYYHASELLTHHTDTHCVTQTPPTQHSSPSVPSGLSSSSQISAVIPELTPEMHTQTGPMPPTLCAQETGAP |
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 412-437 | Disordered | ||||
Sequence: VNESGMEDNSPLPPPVSSLQEKPGRL | ||||||
Region | 520-562 | Disordered | ||||
Sequence: ARTRSESSGHSSPNVTPRASNHSNMSQSEMGHSANEHEDTEDE | ||||||
Compositional bias | 523-550 | Polar residues | ||||
Sequence: RSESSGHSSPNVTPRASNHSNMSQSEMG | ||||||
Domain | 573-834 | Protein kinase | ||||
Sequence: FSPRDVLGHGAEGTIVYRGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCSSTLQEYVERKDFDRHGLEPVTLLEQTMSGLSHLHSLNIVHRDLKPHNILVSMPNTHGRVKAMISDFGLCKKLAVGRHSFSRKSGVPGTEGWIAPEVLSEDAKHNPTCMVDIFSAGCVFYYVVSEGQHPFGKSLQRQANILLGAYSLDHLQPNRHEDIVARNLIEQMLSMEPEKRPSADRVLKHPFF | ||||||
Domain | 837-966 | KEN | ||||
Sequence: LEKQLQFFQDVSDRIEKEPLDGPIVRQLERGGRVVVKGDWRDHITVPLQTDLRRFRSYKGGSVRDLLRAMRNKKHHYRELPDEVQETLGSIPDEFVSYFTSRFPLLLQHTHLAMRFCAAERPFLPYYHAS | ||||||
Region | 976-997 | Disordered | ||||
Sequence: HCVTQTPPTQHSSPSVPSGLSS | ||||||
Region | 1011-1031 | Disordered | ||||
Sequence: EMHTQTGPMPPTLCAQETGAP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,031
- Mass (Da)116,536
- Last updated2019-07-31 v1
- Checksum274AE3393C3C4788
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 523-550 | Polar residues | ||||
Sequence: RSESSGHSSPNVTPRASNHSNMSQSEMG |