A0A4V0YX64 · A0A4V0YX64_MEGAM

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentIRE1-TRAF2-ASK1 complex
Molecular FunctionATP binding
Molecular Functionprotein serine/threonine kinase activity
Molecular FunctionRNA endonuclease activity
Molecular Functionunfolded protein binding
Biological Processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological ProcessIRE1-mediated unfolded protein response
Biological ProcessmRNA processing
Biological Processregulation of gene expression
Biological Processregulation of primary metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • Name
      IRE1

Organism names

Accessions

  • Primary accession
    A0A4V0YX64

Subcellular Location

Membrane
; Single-pass type I membrane protein

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_502020278318-1031non-specific serine/threonine protein kinase

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region412-437Disordered
Region520-562Disordered
Compositional bias523-550Polar residues
Domain573-834Protein kinase
Domain837-966KEN
Region976-997Disordered
Region1011-1031Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,031
  • Mass (Da)
    116,536
  • Last updated
    2019-07-31 v1
  • Checksum
    274AE3393C3C4788
MMAWGVCSRALVWIITAVMWWSHSSLMGFCSSSTVSVPESLLFVSTLDGNLHAVSKRSGTIKWTLKEDPVLQVPTHVSEPAFLPDPNDGSLYSLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDVWYVVDLLTGEKQQTLTSSYAEMLCPSSSLLYLGRTEYTITMYDTKSRELRWNATYSDYAFTLPDDDTKYNMAHFVSNGDGLVVTVDSESGDVQWVQNYNSPVVAIYIWQREGLRKVPHTNVAVETLRYLTFMSGEVGRITQWKYPFPREKKTKDKLMSTLYVGKHSTGLYASPSLVHDGVTVVPRGRTFPMLEGPSNQESSVEDEQECVITPSTTVKFSAALKERNRMNVMRNSLLLIGHHETPPDAHNKILEKFPESIPRQHVNIIPPATEKTIEEKVNESGMEDNSPLPPPVSSLQEKPGRLPRVETPVDSMLKDMATIIFCTFLLAGWVAFIITYPKSVHKQQQLQHQQFQQQMEEKLQLLQRQQLIFQPPTDLPPDTDFLEAARTRSESSGHSSPNVTPRASNHSNMSQSEMGHSANEHEDTEDESNIVRIGNITFSPRDVLGHGAEGTIVYRGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCSSTLQEYVERKDFDRHGLEPVTLLEQTMSGLSHLHSLNIVHRDLKPHNILVSMPNTHGRVKAMISDFGLCKKLAVGRHSFSRKSGVPGTEGWIAPEVLSEDAKHNPTCMVDIFSAGCVFYYVVSEGQHPFGKSLQRQANILLGAYSLDHLQPNRHEDIVARNLIEQMLSMEPEKRPSADRVLKHPFFWSLEKQLQFFQDVSDRIEKEPLDGPIVRQLERGGRVVVKGDWRDHITVPLQTDLRRFRSYKGGSVRDLLRAMRNKKHHYRELPDEVQETLGSIPDEFVSYFTSRFPLLLQHTHLAMRFCAAERPFLPYYHASELLTHHTDTHCVTQTPPTQHSSPSVPSGLSSSSQISAVIPELTPEMHTQTGPMPPTLCAQETGAP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias523-550Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG763105
EMBL· GenBank· DDBJ
QBA09440.1
EMBL· GenBank· DDBJ
mRNA

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