A0A4V0L572 · A0A4V0L572_9ARAC
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Araneae > Araneomorphae > Entelegynae > Araneoidea > Tetragnathidae > Tetragnatha
Accessions
- Primary accessionA0A4V0L572
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGVWSAMVGTAMSVLIRIEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: LYNVIVTAHAFVMIFFMVMPILI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: LFMLFVSSMVDIGVGAGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGASSIMGAINFISTIINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAGAITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: SLYFLFGVWSAMVGTAMSVLIRIELGQSGSFLGDDQLYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMLGAPDMAFPRMNNLSFWLLPPSLFMLFVSSMVDIGVGAGWTVYPPLASLEGHSGSSVDFAIFSLHLAGASSIMGAINFISTIINMRMSGVSMEKVPLFVWSVLITAVLLLLSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPVLFQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,686
- Last updated2019-07-31 v1
- ChecksumFF2E8CC71FFE130B
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ991603 EMBL· GenBank· DDBJ | ADX38354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF884439 EMBL· GenBank· DDBJ | AEC58036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306043 EMBL· GenBank· DDBJ | AEL60487.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306051 EMBL· GenBank· DDBJ | AEL60495.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306056 EMBL· GenBank· DDBJ | AEL60500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306057 EMBL· GenBank· DDBJ | AEL60501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306058 EMBL· GenBank· DDBJ | AEL60502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306060 EMBL· GenBank· DDBJ | AEL60504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306062 EMBL· GenBank· DDBJ | AEL60506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306063 EMBL· GenBank· DDBJ | AEL60507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306064 EMBL· GenBank· DDBJ | AEL60508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306065 EMBL· GenBank· DDBJ | AEL60509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306067 EMBL· GenBank· DDBJ | AEL60511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306068 EMBL· GenBank· DDBJ | AEL60512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306069 EMBL· GenBank· DDBJ | AEL60513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306070 EMBL· GenBank· DDBJ | AEL60514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306071 EMBL· GenBank· DDBJ | AEL60515.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306072 EMBL· GenBank· DDBJ | AEL60516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN306214 EMBL· GenBank· DDBJ | AEL60658.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK153888 EMBL· GenBank· DDBJ | QCW08387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK153931 EMBL· GenBank· DDBJ | QCW08430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK153948 EMBL· GenBank· DDBJ | QCW08447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK153993 EMBL· GenBank· DDBJ | QCW08492.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154014 EMBL· GenBank· DDBJ | QCW08513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154019 EMBL· GenBank· DDBJ | QCW08518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154078 EMBL· GenBank· DDBJ | QCW08577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154115 EMBL· GenBank· DDBJ | QCW08614.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154268 EMBL· GenBank· DDBJ | QCW08767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154462 EMBL· GenBank· DDBJ | QCW08961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154482 EMBL· GenBank· DDBJ | QCW08981.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154508 EMBL· GenBank· DDBJ | QCW09007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154563 EMBL· GenBank· DDBJ | QCW09062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154571 EMBL· GenBank· DDBJ | QCW09070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154624 EMBL· GenBank· DDBJ | QCW09123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154665 EMBL· GenBank· DDBJ | QCW09164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154842 EMBL· GenBank· DDBJ | QCW09341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK154880 EMBL· GenBank· DDBJ | QCW09379.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK155021 EMBL· GenBank· DDBJ | QCW09520.1 EMBL· GenBank· DDBJ | Genomic DNA |