A0A4V0L572 · A0A4V0L572_9ARAC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Araneae > Araneomorphae > Entelegynae > Araneoidea > Tetragnathidae > Tetragnatha

Accessions

  • Primary accession
    A0A4V0L572

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,686
  • Last updated
    2019-07-31 v1
  • Checksum
    FF2E8CC71FFE130B
SLYFLFGVWSAMVGTAMSVLIRIELGQSGSFLGDDQLYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMLGAPDMAFPRMNNLSFWLLPPSLFMLFVSSMVDIGVGAGWTVYPPLASLEGHSGSSVDFAIFSLHLAGASSIMGAINFISTIINMRMSGVSMEKVPLFVWSVLITAVLLLLSLPVLAGAITMLLTDRNFNTSFFDPSGGGDPVLFQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ991603
EMBL· GenBank· DDBJ
ADX38354.1
EMBL· GenBank· DDBJ
Genomic DNA
JF884439
EMBL· GenBank· DDBJ
AEC58036.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306043
EMBL· GenBank· DDBJ
AEL60487.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306051
EMBL· GenBank· DDBJ
AEL60495.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306056
EMBL· GenBank· DDBJ
AEL60500.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306057
EMBL· GenBank· DDBJ
AEL60501.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306058
EMBL· GenBank· DDBJ
AEL60502.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306060
EMBL· GenBank· DDBJ
AEL60504.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306062
EMBL· GenBank· DDBJ
AEL60506.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306063
EMBL· GenBank· DDBJ
AEL60507.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306064
EMBL· GenBank· DDBJ
AEL60508.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306065
EMBL· GenBank· DDBJ
AEL60509.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306067
EMBL· GenBank· DDBJ
AEL60511.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306068
EMBL· GenBank· DDBJ
AEL60512.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306069
EMBL· GenBank· DDBJ
AEL60513.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306070
EMBL· GenBank· DDBJ
AEL60514.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306071
EMBL· GenBank· DDBJ
AEL60515.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306072
EMBL· GenBank· DDBJ
AEL60516.1
EMBL· GenBank· DDBJ
Genomic DNA
JN306214
EMBL· GenBank· DDBJ
AEL60658.1
EMBL· GenBank· DDBJ
Genomic DNA
MK153888
EMBL· GenBank· DDBJ
QCW08387.1
EMBL· GenBank· DDBJ
Genomic DNA
MK153931
EMBL· GenBank· DDBJ
QCW08430.1
EMBL· GenBank· DDBJ
Genomic DNA
MK153948
EMBL· GenBank· DDBJ
QCW08447.1
EMBL· GenBank· DDBJ
Genomic DNA
MK153993
EMBL· GenBank· DDBJ
QCW08492.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154014
EMBL· GenBank· DDBJ
QCW08513.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154019
EMBL· GenBank· DDBJ
QCW08518.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154078
EMBL· GenBank· DDBJ
QCW08577.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154115
EMBL· GenBank· DDBJ
QCW08614.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154268
EMBL· GenBank· DDBJ
QCW08767.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154462
EMBL· GenBank· DDBJ
QCW08961.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154482
EMBL· GenBank· DDBJ
QCW08981.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154508
EMBL· GenBank· DDBJ
QCW09007.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154563
EMBL· GenBank· DDBJ
QCW09062.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154571
EMBL· GenBank· DDBJ
QCW09070.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154624
EMBL· GenBank· DDBJ
QCW09123.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154665
EMBL· GenBank· DDBJ
QCW09164.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154842
EMBL· GenBank· DDBJ
QCW09341.1
EMBL· GenBank· DDBJ
Genomic DNA
MK154880
EMBL· GenBank· DDBJ
QCW09379.1
EMBL· GenBank· DDBJ
Genomic DNA
MK155021
EMBL· GenBank· DDBJ
QCW09520.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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