A0A4U8V0L8 · A0A4U8V0L8_STECR

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

137785001,0001,5002,0002,5003,0003,500
TypeIDPosition(s)Description
Active site3745Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionubiquitin protein ligase activity
Biological Processprotein polyubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HECT-type E3 ubiquitin transferase
  • EC number

Gene names

    • ORF names
      L596_004833

Organism names

Accessions

  • Primary accession
    A0A4U8V0L8

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region714-766Disordered
Compositional bias751-766Polar residues
Region1292-1331Disordered
Compositional bias1302-1331Basic and acidic residues
Compositional bias1998-2020Basic and acidic residues
Region1998-2024Disordered
Region2048-2097Disordered
Compositional bias2057-2077Acidic residues
Region2397-2418Disordered
Region2556-2592Disordered
Region2633-2671Disordered
Compositional bias2635-2653Polar residues
Region2700-2723Disordered
Region3208-3281Disordered
Compositional bias3223-3261Polar residues
Compositional bias3262-3281Basic and acidic residues
Domain3443-3778HECT

Sequence similarities

Belongs to the UPL family. TOM1/PTR1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,778
  • Mass (Da)
    424,948
  • Last updated
    2019-07-31 v1
  • Checksum
    69BDD06079FF95FE
MKLATNKPSGGGDLHPACDAMFQQVLKLDGSKLSAFLETAEWPTNAPKSEMQRWIPVLNKFDRIMECALREDASGRKIVDNKPDVKKLVEEVLRFSWILYENTFSRSVYSSIDRLIELLDVEDICLVTKTLAFLLAISKRSRFISQMQKDLKRELSHRLYAIVLSWDGQTSEVRMTQACNPDFSCQYFPIKVNGRAGPSQQTIVEPDYDKVSLQEMWKQFEEMEKANPIDDQQKHLIRAGIRMAYSMRDYELRMHVVIARLMSFSVLAYSRLCFEHPTVQLQVKNTLIGEIEEILLRPENFEVKIIDKLKCEALRTLTSLVNVDKQSRIRAVIDATGADTYHGYVSAVTRICVDDLKADLIGKSGHMSTQFATALFSLLYHIAGADAPVNHRLARRSYNLSASIMDSLLDVISSDTISVENIGFITRAIRVIDIITSSDGSGFNNIAGIQAAVNRFVIEVRACKDFYSSKPAVDPCNHQRAALMKSLLNFLKQSVSDAHFADACRPMMDGDLPECLNEILDNANFFGGSLFYNAVCLITSFVYQEPTKLTVLQDKGVCDAVMRGMFRYETPMSRDMIAHIPSTLSALCLNERGLETVKNGKYFEKIFNTIFSMKFMTISKKKKAGLVDSAQTLGTSLEELLRHQPSLRSDLYKALVNSIDRIKTMTEDPKNKLVYSAAAAIAMKNGDVESEESSVAPPTTVTVEALPRRQYAGRGRMPRGIRGGRHARTVAGTSNNNELSDDEDDDDATSNEAMTTTGTSNDTEATYSEGFSVGDAYVVPVGEYATYVCRVIETMVAQSTSSENARLFIELGVVQKLIRLLWIRRVCVEMYQNGLQTIIANIVRTLLLNGHNTTVLEDVLMELCEVTSTCSKYDPESEEDVLLGVQDETTGAFLIGLHKDASKVVIEDICSIGSVAQVLLLLIRRPMLAGQTNDIRALLLKHFVNSQYGKRSMENIAKWFRFLTWEMCAWQSKMKISNDEKLDGKKSKKAATKDPNIPTVPLASESESVIVTSDQIGMFGHLAKIQKTVADIQCSIVNAITDFNQKRFVEKMTNDCPKAFVLIDEIFRTVMLNLQWEGAKPVEMTRNLFCSAVIDFLRSLFATTQTMSYCAAITRFFMSQHYETFCNAIGNLANELGSPGIGFVVDAWISVVSDVINCRHGKRGKLKIGKQHEFMFGCKKVDIKAFLSDFRMRTYDNIIAIYASLSDRNELVDLPEHQVNILCKCLQVFTDINASFNKAEIEEIQKRHDDISLLAVTDDSEALTAMGFKDKQAKVALSFLGSNETSANFLSQYTSESKTPRLPSAEEIRRSKKAKKQETEEAARKEELDEVQTPVDDPDVGLYVKNEVPFDLVLRLYRTFFKEHDFVLAEAARYASTMIQQQPLSVQRHIYHRDFISPLVHSMSAFMETYPQKLPIESEFCEDSMGILIREMRFLCLTYHQLPVPALTDLIEPSVVEILFKFFVHVQAERKMPGFARAIEYMSLILELVDKTAIFENRRAMYCESVVCAKWKYWNSVSESFGGESSKKSGWVQFPSWFSSELDSRYKLGYETWDDAEVDGERRCSINFSDMVCSYGETGPVIPITVDVTLKKSVDSQTFLNQDDQSILTINQRLHLLKSCVELLTFEEADADCVHSLLAQITRLLRDYSMVPYFMELKGLETILKLESYKSMGTTPFFVTVILNHCLDNDVLLEETFEKLIRTYLRGGNISAYGGTEGYFNRWPRLRSGRFKEWIHVIHSLSSAGARNSRVLSMVLNKITSKTNDQMEALEKVKVSFPCMEIPPPMFDDLPERVVGILLNYILEHRCTEDDQMLITRSFLLRTLAELTKNYGCVATCIVDIHEHSDVFSTMIELSISSEERHVGDAARAFLMTVASATHSPEVQKALIEAVRQYLNTTVSGNDLPKIVSNIQEIANLLLHFRDACPPNVDVPAEVIERQGNHNAVFWHIVDSGILNDLVNCVWKVKNCEKDDIVKMATAIVKTLEELTRFSGFLKKRDEEEGSNATEVRSETDETEEVHPVDQAPMQAVVDEMTDRYAMDELPVQYETHHETGGDDDHEEDIDEDEEEEDEEEDTEPMDETHARWYEEEEDGEGVMNDLDDEMDTGDDDMSRVDDHILEEVLEDIERAERNDPEFERYGSNVFVLDHAISGDGGFRSTAARNAFGSGPGGPSFGGGGFGSSRYGGLNEWGANGRDSGDVRVLYSRGAGLSSDFLPTLGVDNELGVSSHPLLRHTSQRLGTDGARFVRLGLGSRAISPDWFLNRSVFEPPHVLRTRRLGPNGHVLQRQNAVRRYPHTSMLTAAMYDDSIYRELRRYGDTDLRPKASGRHAVPTSMDRYIESSRLMDNQSITYIFSMICAAYCVPQPTEGKPAKEEGVRYWGLSGEDRNEVETIDLADDDEEEEDSQATNESDAPLQFPPIPNLAPLPLLPLPLPLPPFQPPSLFSNIGNHMANVGHGIPPLLPPSALPGPLAAFLETIMQFHQPPQQEFANITLPTHAESEVSGTFPLPLFLAPPASENRQLQNDDSDIQVLEELSAMSSEDTEEDDDVQVIGVYPSSSNYQMRGNEAPPSTPSAATDPHQANGSQRNEVGPSNELDENLRQILGDLEVPDGVDPAFLAALPEDMRSEVIRDHLRQQGRSSSTSGSQSATPSVPPEPSSENPVGDDASAEAEEEPIIPPLDQEFLAALPPELQEELIQQHERDVRLAREAQNASSAPQAEEPVDPAALLESLPPSLRAQVLADADDSVIQVLPPTMADEARRLRANLEQQQALRYARLPRNLGMGSNGGALSRHREIMRTNESSSPTMNTVQFLNPEALTTVILFLFLDDAKVQPHSPFAMNKLMKLIRNLCNHGPSCDYIILGLTQFMETLSSSAQNFGNIKARGDPNTATWLERLTYNCGMGRHEPLVVFPGGTAVGRRIGPKILRSRRVPGLAEVLPTAVGQPIAAIHPRAIPRCATAVSEALQNIARAFPTQFLPQSMYPVKVDTAGFKKPNFNIFFTAQCILSKWENNKEDLTQFQYPSFSKAPIASVLSVLTGEWLQKTEDVYERLLRICNVVIHKIPDDIMFDGDSDALKNSLRCIVKIITLQGRTETHNDGRLLLAECTRAFGESSKEWIFELLIESIESLGLHFLPELISLEDELSKCCLGNDNDKSGESKELIQSTTIKLSSMKLSGQDQLLDSVQSLIAIRGLIQSIEIKREKNRKAAEAKKAEKQAAQEAIPAQEAISNANPATADNVADPTVDPTVNPTVDPTVSNAEVSTEDKVREASKSVEEEKPPTVEDYEDLKNLEPLWDVLSSCLAKLEAFSGQRAVVTLQPATEAFFLVHTPSSLPDDLTDYMKKHSLLDSNLNRLHEFAEKHRRVLNQILRVSGSQLMEEGGSFRILMLFPKLLDFDVKRKFFRKEIHRRERDDRSFIRRDDVGIRIRRSHLFSDSFRELFRLRSNDWKSRFYVVFEGEEGQDAGGLLREWFSVITREIFNPNYALFSAAPGDRATYMINKASYINPEHLDYFKFVGKIIAKAIYENKLLDCYFTRAFYKHILNLPVRYQDIESEDPSYYKSLEYLLTNPVEHVAELTFSVDVDEFGVVSRRELKENGLQLPVTDDNKEEYVQLVCQMKMTGSIRKQLDAFLEGFYEIIPKQLISIFNEQELELLISGLPTIDIDDLCANTEYKTYTKSSPQIQWFWRALRSFEREDLAKFLQFVTGTSKVPLQGFSTLEGMNGVQKFSIHCDYRSNDRLPAAHTCFNQLDLPQYENYEKLRSMLLMAIRECTEGFGFA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias751-766Polar residues
Compositional bias1302-1331Basic and acidic residues
Compositional bias1998-2020Basic and acidic residues
Compositional bias2057-2077Acidic residues
Compositional bias2635-2653Polar residues
Compositional bias3223-3261Polar residues
Compositional bias3262-3281Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZBU02000001
EMBL· GenBank· DDBJ
TMS38017.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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