A0A4U7TU66 · A0A4U7TU66_SALET

Function

function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

Catalytic activity

  • Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
    EC:3.2.1.52 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan recycling.

Features

Showing features for binding site, site, active site.

134150100150200250300
TypeIDPosition(s)Description
Binding site62substrate
Binding site70substrate
Binding site133substrate
Binding site163-164substrate
Site174Important for catalytic activity
Active site176Proton donor/acceptor
Active site248Nucleophile

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionbeta-N-acetylhexosaminidase activity
Molecular FunctionN-acetyl-beta-D-galactosaminidase activity
Biological Processcarbohydrate metabolic process
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processpeptidoglycan turnover
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-hexosaminidase
  • EC number
  • Alternative names
    • Beta-N-acetylhexosaminidase
    • N-acetyl-beta-glucosaminidase

Gene names

    • Name
      nagZ
    • ORF names
      CB251_11865
      , CC592_03850
      , CCO42_13130
      , DNV25_05325
      , E1C04_02375
      , EJI58_09395
      , G2284_03165
      , G4L22_002743
      , G4L25_002727
      , G9C61_001620
      , GBV50_03100

Organism names

Accessions

  • Primary accession
    A0A4U7TU66

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain12-300Glycoside hydrolase family 3 N-terminal
Region170-189Disordered
Compositional bias175-189Basic and acidic residues

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    37,698
  • Last updated
    2019-07-31 v1
  • Checksum
    E07E83487336A300
MGPVMLNVEGCELDAEEREILAHPLVGGLILFTRNYHDPEQLRELVRQIRAASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFFALHGLEEGGRLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPAKALAMATRFIDGMHDAGMKTTGKHFPGHGAVTADSHKETPCDPRPETDIRGKDMSVFRTLISENKLDAIMPAHVIYRAIDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERAQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRRELMDSARWKTASAQLNQLHERWQEEKAGH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias175-189Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAGQXB010000004
EMBL· GenBank· DDBJ
EBR0233389.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHTQM010000006
EMBL· GenBank· DDBJ
ECA2821745.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHYMQ010000001
EMBL· GenBank· DDBJ
ECB7358975.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMICY010000017
EMBL· GenBank· DDBJ
EDH5859079.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMJLM010000006
EMBL· GenBank· DDBJ
EDH9852296.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHEJ010000001
EMBL· GenBank· DDBJ
HAB5763435.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAQON010000001
EMBL· GenBank· DDBJ
HAE0218236.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASSN010000020
EMBL· GenBank· DDBJ
HAE6844743.1
EMBL· GenBank· DDBJ
Genomic DNA
DAASSR010000018
EMBL· GenBank· DDBJ
HAE6872060.1
EMBL· GenBank· DDBJ
Genomic DNA
DAATXA010000004
EMBL· GenBank· DDBJ
HAF0473957.1
EMBL· GenBank· DDBJ
Genomic DNA
CP075112
EMBL· GenBank· DDBJ
QVZ15436.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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