A0A4U3IJM6 · A0A4U3IJM6_9PSED

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
Catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site31-38GTP (UniProtKB | ChEBI)
Binding site110-114GTP (UniProtKB | ChEBI)
Binding site165-168GTP (UniProtKB | ChEBI)
Binding site471-478ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )
  • Recommended name
    Adenylyl-sulfate kinase
  • EC number
  • Alternative names
    • APS kinase
    • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
    • Adenosine-5'-phosphosulfate kinase

Gene names

    • Name
      cysC
    • Synonyms
      cysN
    • ORF names
      PspCFBP13528_03855

Organism names

  • Taxonomic identifier
  • Strain
    • CFBP13528
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A4U3IJM6

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-241Tr-type G

Sequence similarities

Belongs to the APS kinase family.
In the C-terminal section; belongs to the APS kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    632
  • Mass (Da)
    68,907
  • Last updated
    2019-07-31 v1
  • Checksum
    C54F17C85BD54BED
MSHQSDLISEDILAYLGQHERKEMLRFLTCGNVDDGKSTLIGRLLHDSKMIYEDHLEAITRDSKKSGTTGNDIDLALLVDGLQAEREQGITIDVAYRYFSTAKRKFIIADTPGHEQYTRNMATGASTCDLAIILIDARYGVQTQTRRHSFIASLLGIKHIVVAVNKMDINGFDQRVFESIKADYLKFADGIAFKPSTLAFVPMSALKGDNVVNKSERSPWYTGQSLMEILETVEIANDRNYTDLRFPVQYVNRPNLNFRGFAGTLASGIVHKGDEVVVLPSGKSSRVKSIVTFEGELEHAGPGQAVTLTMEDEIDISRGDLLVHADNVPQVTDAFDAMLVWMAEEPMLPGKKYDIKRATSYVPGSITSIVHRVDVNTLAEGPASSLQLNEIGRVKVSLDAAIALDGYDSNRTTGAFIVIDRLTNGTVAAGMIIAPPVNHGGSAQHGSLAHVATEERALRFGQQPATVLFSGLSGAGKSTLAYAVERKLFDMGRAVFVLDGQNLRHDLNKGLPQDRAGRTENWRRAAHVARQFNEAGLLTLAAFVAPDAEGREQAKALIGADRLLTVYVQASPLVCAERDPQGLYAAGGDNIPGESFPYDVPLNADLVIDTQSLSLEDSVKQVLELLRQRGAI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGAJ01000002
EMBL· GenBank· DDBJ
TKK34755.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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