A0A4U3IHH8 · A0A4U3IHH8_9PSED
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids634 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 46 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 73 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 114-120 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLHGVGI | ||||||
Binding site | 338 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Site | 450 | Interaction with DNA | ||||
Sequence: N | ||||||
Site | 501 | Interaction with DNA | ||||
Sequence: H | ||||||
Site | 619 | Interaction with DNA | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A4U3IHH8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 416-529 | Toprim | ||||
Sequence: SELFLVEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGSEVLASQEVHNIAVAIGVDPGAADMSQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPP |
Sequence similarities
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)69,378
- Last updated2019-07-31 v1
- ChecksumFCFC07334F7693DF