A0A4U3IHH8 · A0A4U3IHH8_9PSED

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

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TypeIDPosition(s)Description
Binding site9ATP (UniProtKB | ChEBI)
Binding site46ATP (UniProtKB | ChEBI)
Binding site73ATP (UniProtKB | ChEBI)
Binding site114-120ATP (UniProtKB | ChEBI)
Binding site338ATP (UniProtKB | ChEBI)
Site450Interaction with DNA
Site501Interaction with DNA
Site619Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      PspCFBP13528_08630

Organism names

  • Taxonomic identifier
  • Strain
    • CFBP13528
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A4U3IHH8

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain416-529Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    634
  • Mass (Da)
    69,378
  • Last updated
    2019-07-31 v1
  • Checksum
    FCFC07334F7693DF
MATPSASSYNADAIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSVQVILHADHSLEVSDDGRGMPVDIHPEEGVSGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTQVRVKVKRDGNEYQMTFADGYKATDLEVIGSVGKRNTGTSVYFAPDPKYFDSPKFSISRLKHVLKAKAVLCPGLLVSFEDKGTGEKVEWHYEDGLRSYLEDSVSDFERLPNAPFCGSLAGNKEAVDWALLWLPEGGDSVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEYRSLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNEHPELGLALAELAINNAGRRLKASKKVERKRITQGPALPGKLADCAGQDPMRSELFLVEGDSAGGSAKQARDKEFQAILPLRGKILNTWEVDGSEVLASQEVHNIAVAIGVDPGAADMSQLRYGKICILADADSDGLHIATLLCALFVQHFRPLVDAGHVYVAMPPLYRIDLGKEIFYALDEAERDGILDRLVAEKKRGKPQVTRFKGLGEMNPPQLRETTMDPNTRRLVQLTLEDFAGTSEMMDMLLAKKRAPDRKAWLESKGNLAEVLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QGAJ01000003
EMBL· GenBank· DDBJ
TKK33751.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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