A0A4U3CC88 · A0A4U3CC88_9ACTN
- ProteinPorphobilinogen deaminase
- GenehemC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Miscellaneous
The porphobilinogen subunits are added to the dipyrromethane group.
Catalytic activity
- 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4+
Cofactor
Note: Binds 1 dipyrromethane group covalently.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | hydroxymethylbilane synthase activity | |
Biological Process | peptidyl-pyrromethane cofactor linkage | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePorphobilinogen deaminase
- EC number
- Short namesPBG
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Geodermatophilales > Geodermatophilaceae > Blastococcus
Accessions
- Primary accessionA0A4U3CC88
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 241 | S-(dipyrrolylmethanemethyl)cysteine | |||
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-212 | Porphobilinogen deaminase N-terminal | |||
Domain | 225-298 | Porphobilinogen deaminase C-terminal | |||
Sequence similarities
Belongs to the HMBS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)31,663
- Last updated2019-07-31 v1
- Checksum0D121B928D3F85B7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LWUA01000296 EMBL· GenBank· DDBJ | TKJ16526.1 EMBL· GenBank· DDBJ | Genomic DNA |