A0A4U3CC88 · A0A4U3CC88_9ACTN

Function

function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

dipyrromethane (UniProtKB | Rhea| CHEBI:60342 )

Note: Binds 1 dipyrromethane group covalently.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydroxymethylbilane synthase activity
Biological Processpeptidyl-pyrromethane cofactor linkage
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Porphobilinogen deaminase
  • EC number
  • Short names
    PBG
  • Alternative names
    • Hydroxymethylbilane synthase
      (HMBS
      )
    • Pre-uroporphyrinogen synthase

Gene names

    • Name
      hemC
    • ORF names
      A6V29_13865

Organism names

  • Taxonomic identifier
  • Strain
    • CCUG 61487
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Geodermatophilales > Geodermatophilaceae > Blastococcus

Accessions

  • Primary accession
    A0A4U3CC88

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue241S-(dipyrrolylmethanemethyl)cysteine

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-212Porphobilinogen deaminase N-terminal
Domain225-298Porphobilinogen deaminase C-terminal

Sequence similarities

Belongs to the HMBS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    31,663
  • Last updated
    2019-07-31 v1
  • Checksum
    0D121B928D3F85B7
MLRLGTRASTLAHTQSQGVADAITAATGTPVQLVHITTEGDRSRAAIQQLGSTGVFVAALRDALLAGEVDLAVHSCKDLPTAPQPGLILAAVPGREDPRDALVARDGLTLGELPPGSRVGTGAPRRVAQLRALGLGLEVVPIRGNVETRLGRVAGSATGPGDLDAVVLARAGLSRIGLLDVITETLDPLQVLPAPAQGALAVECRTSDARTRELLGRLEDPITRACVLAERTTLGTLEAGCSAPVAAYAEVADGEDGLELYLRASVTAIDGSDGIRGSLTGPLADAAALGRALAEDLLDRGAVELMAVEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWUA01000296
EMBL· GenBank· DDBJ
TKJ16526.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help