A0A4U1EQ26 · A0A4U1EQ26_MONMO

Function

function

Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentfibrillar center
Cellular Componentplasma membrane
Molecular Functionplatelet-activating factor acetyltransferase activity
Biological Processpositive regulation of macroautophagy
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-activating factor acetylhydrolase IB subunit alpha2
  • EC number
  • Alternative names
    • PAF acetylhydrolase 30 kDa subunit
    • PAF-AH subunit beta

Gene names

    • Name
      PAFAH1B2
    • ORF names
      EI555_002620

Organism names

  • Taxonomic identifier
  • Strain
    • MVW
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Monodontidae > Monodon

Accessions

  • Primary accession
    A0A4U1EQ26

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a catalytic dimer which is either homodimer (alpha2/alpha2 homodimer) or heterodimer with PAFAH1B3 (alpha2/alpha1 heterodimer). Component of the cytosolic (PAF-AH (I)) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts (homodimer form) with PAFAH1B1 (homodimer form); PAFAH1B2 competes with NDEL1 for PAFAH1B1 binding. Interacts with VLDLR; this interaction may modulate the Reelin pathway.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-203SGNH hydrolase-type esterase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    229
  • Mass (Da)
    25,569
  • Last updated
    2019-07-31 v1
  • Checksum
    14CF5D48621AA504
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RWIC01000957
EMBL· GenBank· DDBJ
TKC38659.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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