A0A4U0YQ29 · A0A4U0YQ29_9GAMM

  • Protein
    Penicillin-binding protein 1B
  • Gene
    mrcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site237Proton donor; for transglycosylase activity
Active site515Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentpeptidoglycan-based cell wall
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1B
  • Short names
    PBP-1b
    ; PBP1b
  • Alternative names
    • Murein polymerase

Gene names

    • Name
      mrcB
    • ORF names
      FAZ79_02240

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SB14A
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Chromatiales > Thioalkalibacteraceae > Guyparkeria

Accessions

  • Primary accession
    A0A4U0YQ29

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane66-88Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-19Polar residues
Region1-56Disordered
Compositional bias34-49Polar residues
Domain115-198Bifunctional transglycosylase second
Domain211-384Glycosyl transferase family 51
Domain479-717Penicillin-binding protein transpeptidase

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    821
  • Mass (Da)
    90,454
  • Last updated
    2019-07-31 v1
  • Checksum
    80F500571084AE54
MNVASRKGSGSTKANSTAKGGARGSKARGSRSRRTTAGKTTNRRQAARGTRQGRPNRGWRARLFGWALRGVLLAAAIGLPLLAAWGWYLNERVTERFEGALFTMPATVYAAPDEIYVGQSIDLDSLTAALERLNYVAADSLEETGTFRRRGNQVSFHRRSFAFPDGEQPSRRVDVRIVGGQVTELDGPDGESLGIVRLEPRSIGTLYPNRAEDRVLLAIEEVKEEAPLLLDTLLAVEDRAFHDHHGVVPTAILRAFLTNLVSGERVQGGSTITQQLAKNLFLTHERTYRRKFAEMIMALEMEWHYPKDKILEAYLNEVYLGQDGGRAIHGFGLAASFYFGRPINELKPEQVALLVGMVKGANYYNPRRNPERALARRNVVIDVMIELGLVDQTTGAEWQGRPLGVLDGAGSRARHPAFVDLVRRQLVEQYDPEDLQTRGLNIFTTLRPRVQEALEQSTARLDEVEASRGLEGGTLETAGVIASVSTGEIEAMIGGRDVHYEGYDRALDARRQIGSLIKPAIYLTALSRPAEYNLITEIADEPITVEQRGSEDWEPQNYGRDFRGPTPLIEALAHSRNVPSVRLGMDVGLDSVAETIERLGGPRPSPFYPSMLLGSMGMTPFEVAQMYQTLSADGFMTPLRAIRSVVDRDGKPLSRYSLDVRRAADREPLYLLQYGLQTVVAEGTSTRLNQMIPPSVGVAGKTGTTNDGRDAWFAGFTGNRVGVIWVGRDDDRPANLTGSTAALPLWGATFATLDNQPRDMTPPRGIRFARVDPEREFVVPDRCPGEALPFIASHLPDAATDCDGGRGGRDDDAGTIWDWFR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues
Compositional bias34-49Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SWAW01000003
EMBL· GenBank· DDBJ
TKA91103.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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