A0A4U0WVR3 · A0A4U0WVR3_9PEZI

  • Protein
    Phosphatidyl-N-methylethanolamine N-methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site936Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site1073-1075S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site1155-1156S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionmonooxygenase activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidyl-N-methylethanolamine N-methyltransferase
  • EC number
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • ORF names
      B0A55_09089

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CCFEE 5184
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Mycosphaerellales > Teratosphaeriaceae > Friedmanniomyces

Accessions

  • Primary accession
    A0A4U0WVR3

Proteomes

Subcellular Location

Endomembrane system
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-986Lumenal
Transmembrane109-128Helical
Transmembrane134-159Helical
Transmembrane180-199Helical
Transmembrane214-234Helical
Transmembrane246-267Helical
Transmembrane287-312Helical
Transmembrane333-355Helical
Transmembrane381-407Helical
Transmembrane419-441Helical
Transmembrane447-469Helical
Transmembrane490-512Helical
Intramembrane987-1007Helical
Transmembrane989-1007Helical
Topological domain1008-1019Lumenal
Transmembrane1019-1038Helical
Topological domain1042-1068Cytoplasmic
Transmembrane1058-1080Helical
Topological domain1090-1132Lumenal
Transmembrane1092-1110Helical
Transmembrane1130-1151Helical
Topological domain1154-1175Cytoplasmic

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-53Disordered
Region61-80Disordered
Domain102-513Amino acid transporter transmembrane

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.
Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,175
  • Mass (Da)
    128,842
  • Last updated
    2019-07-31 v1
  • Checksum
    A068022C40E79CFA
MALNNDYGRQGDGELPPPSPDRYQPTSTFGKEGYYDGFGADAEKGGYPGQARKMSRIDKPITKSIGGLNPGADLTADDDTDPSISVGKQMELEAGNSIKYRTCSWQKTAALLFSEYICLAIMSFPYSYSVLGLIPGLILTVVVAGLVLYTSLVVWEFCLRHPEVKDVCDIGQMLFWNSRWAWWATAVMFLLNNTFIQGFHCLVGSKYMNTMAGVDHHICTVGFSAIMAFVSFFCSLPRTFSTLAKLATLSALTTFISVLLATIFAGIENHPRGVAGMRWPTQGPVTYLLVPSSTTTFVAGMNAFMNISYTFIGQITIPSFIAEMKEPKDFPKALWAVTIAEVIVFSLVGAIIYVYTGTAYNTAPAFGSLGNETYLKVSFSFMIPTLIFLGVLYASVSARFVFFRLYAGTRHLGNNTVKGWLGWSAILAVTWVFAFIIAEVIPFFSDLLSLMSSLFDSFFGFIFWGVAYLRMRRADYGPQFWKVNGVRSMAMAALNVACILIGLLFLTAGTYASVESIKQGYDSAAFGGPFSCLSNGVQSRPNSIPSINRRPGDWTNKRAQASFMSNAKILIDSGLEKFSGPFSIATTFGDRIILPPSPQYIEWVKSNLHLSHQASVGADFFAGYPGFEGIDAVNDPRHLMIDVVKKHLSKNESSIAVAGKQLQQCLDSAWTNDAEWHSVDWGSDATTFVALMSAAVFVGPELACNSEWQGLVTSYTMNLFFAARALRSWPAVLRPVVHWLLPNCRKCREQVATARSMLENEFARRKAEKPKNHKDSIEWMEQVAAGRSYDAAAAQLGLAISSIHTTTQLLTQTLIDMCMHPALLEPLRKEVTAATEEHGFTAAGLYNMKLLDSVVKETQRLKPGMLVNLERMATSSVTLPNGIMLPTGTQLAVSSFPSAFPDPETYRGDRFLDDTGGQLVSSSTTHYAFGMGKYICPGRFLVANELKIALASVLTKYDVKLEDGADEPKIACVGFEMLADPTARVQPSLYLSAATILFNPSFWNLAARTEYHRKTLTKLAGGNALYGCYGLALTIFALGLLRDAVYERALRQQPTHPALLSFVSQGLAVGLVASGNVLVLSSMWALGITGTYLGDYFGILMDEMVTGFPFNVTGSPMYWGSTMSFLGTALWFGKPAGVLLTGLVFAAYTVALRFEDPFTAEIYAKREREERKKAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NAJQ01000576
EMBL· GenBank· DDBJ
TKA67411.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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