A0A4U0WVR3 · A0A4U0WVR3_9PEZI
- ProteinPhosphatidyl-N-methylethanolamine N-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1175 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H+
Cofactor
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | mitochondrial membrane | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | monooxygenase activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
Molecular Function | phosphatidyl-N-methylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidyl-N-methylethanolamine N-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Mycosphaerellales > Teratosphaeriaceae > Friedmanniomyces
Accessions
- Primary accessionA0A4U0WVR3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-986 | Lumenal | ||||
Sequence: MALNNDYGRQGDGELPPPSPDRYQPTSTFGKEGYYDGFGADAEKGGYPGQARKMSRIDKPITKSIGGLNPGADLTADDDTDPSISVGKQMELEAGNSIKYRTCSWQKTAALLFSEYICLAIMSFPYSYSVLGLIPGLILTVVVAGLVLYTSLVVWEFCLRHPEVKDVCDIGQMLFWNSRWAWWATAVMFLLNNTFIQGFHCLVGSKYMNTMAGVDHHICTVGFSAIMAFVSFFCSLPRTFSTLAKLATLSALTTFISVLLATIFAGIENHPRGVAGMRWPTQGPVTYLLVPSSTTTFVAGMNAFMNISYTFIGQITIPSFIAEMKEPKDFPKALWAVTIAEVIVFSLVGAIIYVYTGTAYNTAPAFGSLGNETYLKVSFSFMIPTLIFLGVLYASVSARFVFFRLYAGTRHLGNNTVKGWLGWSAILAVTWVFAFIIAEVIPFFSDLLSLMSSLFDSFFGFIFWGVAYLRMRRADYGPQFWKVNGVRSMAMAALNVACILIGLLFLTAGTYASVESIKQGYDSAAFGGPFSCLSNGVQSRPNSIPSINRRPGDWTNKRAQASFMSNAKILIDSGLEKFSGPFSIATTFGDRIILPPSPQYIEWVKSNLHLSHQASVGADFFAGYPGFEGIDAVNDPRHLMIDVVKKHLSKNESSIAVAGKQLQQCLDSAWTNDAEWHSVDWGSDATTFVALMSAAVFVGPELACNSEWQGLVTSYTMNLFFAARALRSWPAVLRPVVHWLLPNCRKCREQVATARSMLENEFARRKAEKPKNHKDSIEWMEQVAAGRSYDAAAAQLGLAISSIHTTTQLLTQTLIDMCMHPALLEPLRKEVTAATEEHGFTAAGLYNMKLLDSVVKETQRLKPGMLVNLERMATSSVTLPNGIMLPTGTQLAVSSFPSAFPDPETYRGDRFLDDTGGQLVSSSTTHYAFGMGKYICPGRFLVANELKIALASVLTKYDVKLEDGADEPKIACVGFEMLADPTARVQ | ||||||
Transmembrane | 109-128 | Helical | ||||
Sequence: AALLFSEYICLAIMSFPYSY | ||||||
Transmembrane | 134-159 | Helical | ||||
Sequence: IPGLILTVVVAGLVLYTSLVVWEFCL | ||||||
Transmembrane | 180-199 | Helical | ||||
Sequence: WAWWATAVMFLLNNTFIQGF | ||||||
Transmembrane | 214-234 | Helical | ||||
Sequence: VDHHICTVGFSAIMAFVSFFC | ||||||
Transmembrane | 246-267 | Helical | ||||
Sequence: LATLSALTTFISVLLATIFAGI | ||||||
Transmembrane | 287-312 | Helical | ||||
Sequence: YLLVPSSTTTFVAGMNAFMNISYTFI | ||||||
Transmembrane | 333-355 | Helical | ||||
Sequence: ALWAVTIAEVIVFSLVGAIIYVY | ||||||
Transmembrane | 381-407 | Helical | ||||
Sequence: FMIPTLIFLGVLYASVSARFVFFRLYA | ||||||
Transmembrane | 419-441 | Helical | ||||
Sequence: GWLGWSAILAVTWVFAFIIAEVI | ||||||
Transmembrane | 447-469 | Helical | ||||
Sequence: LLSLMSSLFDSFFGFIFWGVAYL | ||||||
Transmembrane | 490-512 | Helical | ||||
Sequence: AMAALNVACILIGLLFLTAGTYA | ||||||
Intramembrane | 987-1007 | Helical | ||||
Sequence: PSLYLSAATILFNPSFWNLAA | ||||||
Transmembrane | 989-1007 | Helical | ||||
Sequence: LYLSAATILFNPSFWNLAA | ||||||
Topological domain | 1008-1019 | Lumenal | ||||
Sequence: RTEYHRKTLTKL | ||||||
Transmembrane | 1019-1038 | Helical | ||||
Sequence: LAGGNALYGCYGLALTIFAL | ||||||
Topological domain | 1042-1068 | Cytoplasmic | ||||
Sequence: RDAVYERALRQQPTHPALLSFVSQGLA | ||||||
Transmembrane | 1058-1080 | Helical | ||||
Sequence: ALLSFVSQGLAVGLVASGNVLVL | ||||||
Topological domain | 1090-1132 | Lumenal | ||||
Sequence: GTYLGDYFGILMDEMVTGFPFNVTGSPMYWGSTMSFLGTALWF | ||||||
Transmembrane | 1092-1110 | Helical | ||||
Sequence: YLGDYFGILMDEMVTGFPF | ||||||
Transmembrane | 1130-1151 | Helical | ||||
Sequence: LWFGKPAGVLLTGLVFAAYTVA | ||||||
Topological domain | 1154-1175 | Cytoplasmic | ||||
Sequence: FEDPFTAEIYAKREREERKKAK |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-53 | Disordered | ||||
Sequence: MALNNDYGRQGDGELPPPSPDRYQPTSTFGKEGYYDGFGADAEKGGYPGQARK | ||||||
Region | 61-80 | Disordered | ||||
Sequence: ITKSIGGLNPGADLTADDDT | ||||||
Domain | 102-513 | Amino acid transporter transmembrane | ||||
Sequence: TCSWQKTAALLFSEYICLAIMSFPYSYSVLGLIPGLILTVVVAGLVLYTSLVVWEFCLRHPEVKDVCDIGQMLFWNSRWAWWATAVMFLLNNTFIQGFHCLVGSKYMNTMAGVDHHICTVGFSAIMAFVSFFCSLPRTFSTLAKLATLSALTTFISVLLATIFAGIENHPRGVAGMRWPTQGPVTYLLVPSSTTTFVAGMNAFMNISYTFIGQITIPSFIAEMKEPKDFPKALWAVTIAEVIVFSLVGAIIYVYTGTAYNTAPAFGSLGNETYLKVSFSFMIPTLIFLGVLYASVSARFVFFRLYAGTRHLGNNTVKGWLGWSAILAVTWVFAFIIAEVIPFFSDLLSLMSSLFDSFFGFIFWGVAYLRMRRADYGPQFWKVNGVRSMAMAALNVACILIGLLFLTAGTYAS |
Sequence similarities
Belongs to the amino acid/polyamine transporter 2 family.
Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
Belongs to the cytochrome P450 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,175
- Mass (Da)128,842
- Last updated2019-07-31 v1
- ChecksumA068022C40E79CFA
Keywords
- Technical term