A0A4S8JKM0 · A0A4S8JKM0_MUSBA

  • Protein
    Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta
  • Gene
    PFP-BETA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalytic subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by fructose 2,6-bisphosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site102diphosphate (UniProtKB | ChEBI)
Binding site196Mg2+ (UniProtKB | ChEBI); catalytic
Site197Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Site223Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Binding site224-226substrate
Active site226Proton acceptor
Binding site263-264substrate; ligand shared between dimeric partners
Binding site271-273substrate
Binding site384substrate
Binding site489-492substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta
  • EC number
  • Short names
    PFP
  • Alternative names
    • 6-phosphofructokinase, pyrophosphate dependent
    • PPi-PFK
    • Pyrophosphate-dependent 6-phosphofructose-1-kinase

Gene names

    • Name
      PFP-BETA
    • ORF names
      C4D60_Mb07t26410

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • cv. DH-PKW
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Zingiberales > Musaceae > Musa

Accessions

  • Primary accession
    A0A4S8JKM0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Domain94-306Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    616
  • Mass (Da)
    67,177
  • Last updated
    2019-07-31 v1
  • Checksum
    030479BBD8DAFB2E
MAFANSVLPKGGGKSPSPGRLASVYSEVQTNRLHHPLPLPSVLKGPFKLLDGPPSSAAGNPDEIAKLFPNMFGQPSAKLVPTGSVPADLPEGLKIGVVLSGGQAPGGHNVISGIFDYLQERAKRSTLYGFKGGPAGIMKCKYVDLTPEFIYPYRNQGGFDMICSGRDKIETPEQFKQAEETAMKLDLDGLLVIGGDDSNTNACLLAENFRQKNMKTRVIGCPKTIDGDLKCKEVPASFGFDTACKIYSEMIGNVMTDARSTGKYYHFVRLMGRAASHITLECALQTHPNIAIIGEEPIGKWAKVNQMDQADMRHIILYGSCTIQCGPCTCLGPFSIGLLLGLLPRIGLVAAKKQTLKNVTDYITDIICKRAKLGYNYGVILIPEGLIDFIPEVQQLIAELNEILAHDVVDKEGLWKNKLQQQSQLLFEFLPQAIQEQLLLERDPHGNVQVAKIETEKMLISMVETELEKRKSEGTYAGHFKGQSHFFGYEGRCGLPTNFDAAYCYALGYAAGALLHSGKTGLISSVGNLDAPVDEWTVGGTALTSLMDVERRHGKFKPVIKKAMVELEGAPFRKFASMRDEWALKNRYISPGPIQFIGPGSNNVNHTLLLELGAQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PYDT01000005
EMBL· GenBank· DDBJ
THU61732.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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