A0A4S4L0I6 · A0A4S4L0I6_9AGAM
- ProteinAdenylate kinase isoenzyme 6 homolog
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids187 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
Catalytic activity
- AMP + ATP = 2 ADP
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 20 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 22 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 23 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 24 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 25 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 119 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | phosphorylation | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase isoenzyme 6 homolog
- EC number
- Short namesAK6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Russulales > Bondarzewiaceae > Bondarzewia
Accessions
- Primary accessionA0A4S4L0I6
Proteomes
Interaction
Subunit
Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 42-65 | NMPbind | ||||
Sequence: NVGDLIKEKSLHEGFDEEWQSYTV | ||||||
Region | 118-128 | LID | ||||
Sequence: KRGYPLKKIQE |
Sequence similarities
Belongs to the adenylate kinase family. AK6 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length187
- Mass (Da)21,314
- Last updated2019-07-31 v1
- Checksum92EEF388E6FAE785
Keywords
- Technical term