A0A4S2KDK5 · A0A4S2KDK5_9HYME

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • nonan-2-one + NADP+ = (3E)-nonen-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • octanal + NADP+ = (2E)-octenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • pentan-2-one + NADP+ = (E)-pent-3-en-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendocytic vesicle
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Molecular Function15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Molecular Function2-alkenal reductase [NAD(P)+] activity
Biological Processendocytosis
Biological Processprostaglandin metabolic process
Biological Processprotein localization
Biological Processretrograde transport, endosome to Golgi

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • ORF names
      DBV15_04079

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Formicoidea > Formicidae > Myrmicinae > Temnothorax

Accessions

  • Primary accession
    A0A4S2KDK5

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1197-1239Disordered
Compositional bias1211-1225Acidic residues
Domain2154-2471Enoyl reductase (ER)

Sequence similarities

Belongs to the HEATR5 family.
Belongs to the NADP-dependent oxidoreductase L4BD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,747
  • Mass (Da)
    301,852
  • Last updated
    2019-07-31 v1
  • Checksum
    B057FA967D7638F0
MACACVHLLETMMELSHSLTLNEDALNQIPEAKRPVFIFEWLRFLDKVLVAAQKSDIKGCQQKLVEQLTRHMQGAPGPPTRRLIARCLATLFSVGDTFLLFDTVNKCNDILRNKDDSPSFLPTKLAAICCVGCMYEKLGRMMGRSYEETVQILIKSLRSAESQTRIEIMHTLEKVCAGMGSAITNVHKEIYKVSRHYLTDRVMAVRCAAAKCLLEMLNHAPFLYTTEIESVATLCFRAFEGSNYEVRCSVAKLLGTLVAMTQLPSPKIKNPTVAHNKGAKQASLEEVLNILMSGFLRGGVGFLKGTGEIIKGSSSINREVRVGVTHAYVVFVQMLGGTWLERNIGTLIAHVLDLVTNPKAASSHVEAVYSRKCVNFILRGTIGKLLGEGAQAAACKEIAHIILKQMNSIDFSPENAKDCNQETLFSQHLLVCALQEMGNLILGLGTTATNLLSDQSLSLIDAIMAVLVHPCQAARLAASWCLRCICVAVPSQITPLIDRCVDGIENMRSSPEAIAGYSSALAAVLGSVRLSPLGVPHTKGKIIFNTAEELLRSASQNSRLSLNRTHAGWLLIGAIMTLGTAVVKGLLPRMLLLWRNSFPRSNKELESEKARGDAFTWQVTLEGRAGALSAMYSFLLHCPELLNDDITRRLLTPIESALAMLTNLSPVLKNYGQQLKAPAAMVRLRLYETLLLLPPQMFEGSYTHLLRMLVSEFTLTDNPGNTTTSLLSVVCHANDSVILGTWLQETDHRTIEDQMEPNRRADLEHLQPNSAAGSGALEHNTCCLYRPMPHFEMIPGPLPLGVAVIDLSVALFGQIFPRVANKHRLQMLDHFSECIKHTKSGRQEAIQMNVFTAVLSGLKGLNEAKTGFGQEDVKKSATNLIISTLVSSNPILRWAAGEAVGRMAQVISDPKFTAELAQTSFDRLKSARDVASRTGHSLALGCLHKYVGGMGSSQHLNTSVSILLALAQDNSSPVVQVWALHALALIADSGGPMFRGYVEPTLSLALTLLLNVPHSYIDVHQCIGKVLSALITTIGPELQGNTTTICMARSSFLCACAIMQDHQDPLVQAEATGCLQQLHLFAPRHRTLSSNHLLLRKAAISCLRQLAQREAKEVCEHAMTLANESRDTNVVEGLVITETGLPGVLFSMLDTETDSKLIKDIHDTLTSMLHILAADNLSQWLSLCKDVLTIASESSTIEEGNAANAEDSAADNESADAEGDDDQAEFHADESTKQRPSITPRWPTRVFAAQCVRRIVAACMSDKQAHFDLALAKEMQQSKGKGDFLVLHLSDLVRMAFMAATSDCDPLRLEGLKTLQEIIDKFAKVPEPEFPGHLLLEQFQAQVGAALRPAFSAETPSHVTAAACEACSAWIGSGVARDLNDLRRVHQLLVSSLEKLREGKTRPQLYNESLSTLERLAILKAWAEVYVVAMIRDGSALNSKDTTNRNANQVDETNEEDFGEFEFQSESLLSLVQPELLSLSQHWLSALRDHALLSLPPEFSSQLPHDGGAFYTTDTMESARPHYVESWAPILHAATLWLNARGFEMEDSNQDKATTNLANNNNHNNNNNNDEATACKTNTNVERFHLLFGICMEALCSPRSSESPQNMKTCLNALYTLLDSTWARKVFITDRSLPIELCNVLHRLLLTRESYVIQMIVMEVLKQVMKAAQEDLAARKKLKLKDNASAHQENTETSELDLLGEGEENGELTPGSSLVFAVLEVCLCLLVRQIPALNPNPGGATAILSQKGYVPSEKSGKLIASSLNIMESLPTLCSPQGAVAILPTLLYLATGVIRETAVRTDNDSTKAGSETPVHAALHCVKSLISNKYARDHRSQEQWTGLLRSALAKIIDLAKTGSDETKMDEVAMMLGIAVFVLHASPDVVSAPNLQFPCINHFRHAFQSENLTVRLKCVQTLRTIFLHPERNVSTPYIHALAPRLVEYLYSDKSKQVTNDMELTFTLECVSTVEALIGLADLSNRIQMLTLLVPILINYLLEGDELQHATKYQASLHQQSFQWLNKIGPKYPQEFKTLMSQSTELKIKLENAVRTSHQQAQRHIRPVDPMQAEKTYTAIRSTRSAFENMFKLFKVVQRELSWGRHHFNATVIACPFRDNVNDVTATRLNTRSPWTRKFSTHLREMVKARKYVVVSHFVNEAKPTDLKLVEEELPPLKNGEYLVEAEYFSVDPYMRPYVQRFPLGITMIGGQVAKIIESKNPDFPVGKKIVASLGWRTHTIVNPNVVDDTALQQPYILPDIGDLPASLGLGVLGMPGNTAYFGLMEICKPKPGETIVITGAAGAVGSHVGQIAKNLGLTVIGICGSDEKCKWLTEELGFDSAINYKTMPIAASIRKAAPHGVDCYFDNVGGEISSTVMYQMRQFGRVAVCGSISSYDADASSLPKCGILQPTIVFNQLKIEGFVVTRWNDRWNEGIMQNLRLIREGKLHYRETVTKGFENMFDAFMGMLRGENIGKAIVQAYLGTTVWNLLFTGILPFSSLSMPRSSRPKFCVYGLLPTHTNNTSHAKSSFLLESFASSTETMISLPRLLAAVTFVPSLNFSPCFASIFCMLLLTSPSMPMPPIVGMNSTAVTSEPTHYLCQTEPNSNPMTPAPMTMSLLGTSLSDSAPVEDTTCFSSISMPAKGVTSLPVAIRIFFALIVDSTDPDFDGMHPTLRHVPPRVGSFSTHTVFMPNCAALIAATYPPGPDPITTTSASSVLAYLRCWVLVMPEGVTGEQLKRTDFGGTPTSPTQRKQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1211-1225Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QBLH01002793
EMBL· GenBank· DDBJ
TGZ46916.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp