A0A4R9PK43 · A0A4R9PK43_9HYPH

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site80-82substrate
Binding site93substrate
Binding site97-99substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      EN874_031655

Organism names

Accessions

  • Primary accession
    A0A4R9PK43

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-159dUTPase-like

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    16,644
  • Last updated
    2019-07-31 v1
  • Checksum
    628AD7014C5AD2D5
MRTAVYPSSVIGPTVGFVRLPHGEGLPLPAYESAGAAGMDLRAAVPEDRPLLILPGKRALVPTGLVLEIPEGMEGQVRPRSGLAFKHGLTVLNTPGTIDSDYRGEVKVLLVNLGDEDFAVTRGVRIAQIVFAPVTQVASEERALAGGTARGSGGFGSTGTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RZOZ02000024
EMBL· GenBank· DDBJ
TGP17921.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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