A0A4R8EUR4 · A0A4R8EUR4_9BACT

  • Protein
    Multifunctional fusion protein
  • Gene
    tpiA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site21-23substrate
Binding site36substrate
Binding site59-62substrate
Binding site118substrate
Binding site151substrate
Binding site201ATP (UniProtKB | ChEBI)
Binding site293ATP (UniProtKB | ChEBI)
Binding site324ATP (UniProtKB | ChEBI)
Binding site353-356ATP (UniProtKB | ChEBI)
Binding site410-412substrate
Active site496Electrophile
Active site568Proton acceptor
Binding site574substrate
Binding site614substrate
Binding site635-636substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionADP binding
Molecular FunctionATP binding
Molecular Functionphosphoglycerate kinase activity
Molecular Functiontriose-phosphate isomerase activity
Biological Processgluconeogenesis
Biological Processglycolytic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Triosephosphate isomerase
  • EC number
  • Short names
    TIM
    ; TPI
  • Alternative names
    • Triose-phosphate isomerase
  • Recommended name
    Phosphoglycerate kinase
  • EC number

Gene names

    • Name
      tpiA
    • Synonyms
      pgk
    • ORF names
      C8D74_1039

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 13575
  • Taxonomic lineage
    Bacteria > Thermotogota > Thermotogae > Petrotogales > Petrotogaceae > Petrotoga

Accessions

  • Primary accession
    A0A4R8EUR4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.
Monomer.

Family & Domains

Sequence similarities

Belongs to the phosphoglycerate kinase family.
Belongs to the triosephosphate isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    655
  • Mass (Da)
    71,655
  • Last updated
    2019-07-31 v1
  • Checksum
    6491FB249ED95064
MEKLTIKDVELKGKKVIMRVDFNVPIKDGKITDETRIKAALNTIKYALDKGAKVILLSHLGRPKGEKDPQFSLKPVAERLGELLNTNVYFVDETRGSKVEEAVSELKEGEVLVLENTRFEKGETKNDLELAKYWASLADLHVNDAFGTAHRAHASNVGIANFIPSVAGFLMEKEIEFLQKAVENPEKPYVVILGGAKVSDKIGVINNLLNKADKILIGGAMMFTFLKALGKNVGSSLVEEDKLNVAKEILENSKAKGVEIVLPVDTVIAQKIEAGVEKKTVKIDDGISEGWMGLDIGAETISLFKEKISDAKTIVWNGPMGVFEIDDFAFGTKEVAHVIAEVTKKGCISIIGGGDSAAAAEKFGLASEFSHVSTGGGASLEFLEGKELPGISSISEKKNLNERKFILAANWKMNKTNTEAAEFVSKLVGQIKTEDKFEVIVCPPYTALEKVRDITSSSNIKVGAQNVYYEDKGAYTGEISVNMLKDIGVEYVILGHSERRHIFKESDGLINKKLKKVIVSGLTPILCVGEQLEEREKGLTFNVVERQIKEALYGLTEEEARTIVIAYEPVWAIGTGKVATPNQAQEVHEFIRDLLKDIFNEEFAENTAILYGGSIKPNNYLGLFGKPDIDGGLVGGASLTEDFVELANIMKEIIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SODZ01000003
EMBL· GenBank· DDBJ
TDX16334.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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