A0A4R8EEU8 · A0A4R8EEU8_9BACT

  • Protein
    Imidazolonepropionase
  • Gene
    hutI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Fe3+ (UniProtKB | Rhea| CHEBI:29034 )

Note: Binds 1 zinc or iron ion per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site88Fe3+ (UniProtKB | ChEBI)
Binding site88Zn2+ (UniProtKB | ChEBI)
Binding site90Fe3+ (UniProtKB | ChEBI)
Binding site90Zn2+ (UniProtKB | ChEBI)
Binding site974-imidazolone-5-propanoate (UniProtKB | ChEBI)
Binding site1604-imidazolone-5-propanoate (UniProtKB | ChEBI)
Binding site160N-formimidoyl-L-glutamate (UniProtKB | ChEBI)
Binding site1944-imidazolone-5-propanoate (UniProtKB | ChEBI)
Binding site259Fe3+ (UniProtKB | ChEBI)
Binding site259Zn2+ (UniProtKB | ChEBI)
Binding site2624-imidazolone-5-propanoate (UniProtKB | ChEBI)
Binding site334Fe3+ (UniProtKB | ChEBI)
Binding site334Zn2+ (UniProtKB | ChEBI)
Binding site336N-formimidoyl-L-glutamate (UniProtKB | ChEBI)
Binding site338N-formimidoyl-L-glutamate (UniProtKB | ChEBI)
Binding site3394-imidazolone-5-propanoate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionimidazolonepropionase activity
Molecular Functioniron ion binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazolonepropionase
  • EC number
  • Alternative names
    • Imidazolone-5-propionate hydrolase

Gene names

    • Name
      hutI
    • ORF names
      C8D74_1269

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 13575
  • Taxonomic lineage
    Bacteria > Thermotogota > Thermotogae > Petrotogales > Petrotogaceae > Petrotoga

Accessions

  • Primary accession
    A0A4R8EEU8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-420Amidohydrolase-related

Sequence similarities

Belongs to the metallo-dependent hydrolases superfamily. HutI family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    46,984
  • Last updated
    2019-07-31 v1
  • Checksum
    61718612E2628FC1
METNMSEKATLVIKNISNLITMKGPNRPRKKEEMSEIGLIKNGIIAASKDKIIYVGSGDLPKDIEISQDAKIINAQGKTVTPGLIDPHTHLVHGGSREYELFKKLKGESYLDILSSGGGIYDTVESTKKTSFEELLKKAEKSLNRMLSYGVTTVEAKSGYGLDDFDTELKQLEVIRELNRIHPVDLVPTFLGAHAVPKKYEGNVDKFVDILIREMIPYVAEKDLAKFCDIFCEKGVFLVDQSRKILSAAKEHGLFLKIHADEIEPLGGAELAAELGCISADHLVGASDEGLKKMAKSNVIATLLPTTTFFLQSEKYANARKMIDLGIPIALSTDYNPGSSPTENLQLVMTFGALKLHMNPKEIITSVTINAACALKLEDKIGSLEVGKKADITIFDVPNIEYLIYHFGVNHTQTVIKNGEVYDIAAVS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SODZ01000026
EMBL· GenBank· DDBJ
TDX09959.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help