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A0A4R5NP73 · A0A4R5NP73_LENBU

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

1886100200300400500600700800
TypeIDPosition(s)Description
Binding site532ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      C5L32_000265

Organism names

Accessions

  • Primary accession
    A0A4R5NP73

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, motif, coiled coil.

Type
IDPosition(s)Description
Domain21-438Aminoacyl-tRNA synthetase class Ia
Motif49-59'HIGH' region
Domain442-568Aminoacyl-tRNA synthetase class Ia
Motif529-533'KMSKS' region
Domain612-758Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Coiled coil816-885
Domain818-882Valyl-tRNA synthetase tRNA-binding arm

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    886
  • Mass (Da)
    102,462
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    D3FC40FE201B85C275658CB2B79DBF4C
MSDKLHEMSTKYDPTAVEKGRYDEWLDEGVFTPSGDKKAKPFSIVLPPPNVTGKLHLGHAWDTTLQDMIIRRKRMQGYDTLWLPGMDHAGIATQAKVEAKLRKQGISRYDLGREKFVEKVWEWKDDFARTIKEQWAKLGLSLDYSRERFTLDKGLSKAVRKVFVTLYNKGLIYRGEYIINWDPQARTALSDIEVIHKDDKGAFYHVKYPFTDGTTFNGKDYIEIATTRPETMMGDTAVAVNPSDERYKDIVGKKVRVPLINREVPIIADQYVDPDFGTGMVKITPAHDPNDFKVGNRHNLQRINTMNEDASMNENAGKYKGMDRFEARKAMVKDLQDEGLMLSIDPIVHSVGHSERTGVQVEARLSTQWFVKMKPLAEQAIKNQDTNNKVNFFPDRFEGTFEQWMENVHDWVISRQLWWGHQIPAWYNKQTGEIYVGMEAPKDAENWEQDPDVLDTWFSSALWPFSTMGWPDDTEDMKRYFPTDTLVTGYDIIFFWVSRMIFQSLEFTHERPFKDVLLHGLIRDSQGRKMSKSLGNGIDPMDVIDKYGADALRWFLSIGGTPGQDLKFSYDKMDSAWNFINKIWNASRYVIMNLDGIDKPELPDKSEWQLSDKWILSRLNATVNHVSDLFEKYNFGEADRYLYDFIWNDFCDWYIEMSKEALNSDDEKLKKNTQNILAYVLDQTLRLLQPIMPFVTEYIWQMMPHVGKSLVTADYPVDHKEFDDPTSEHQMQSLIDLITAVRNIRNEANAPLSSPIDMLIQTDNQTLKSIFESNRDYIDRFCHTQELQIGKDIEAPKLSMSAVITDATVFVPLAELVDLKDEQARVQKDVDKFEAEVARSDKKLANKRFVENAPDAVVAEEKAKQADYQSKLDAAKDRLQQISSEM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PUFP01000052
EMBL· GenBank· DDBJ
TDG77612.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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