A0A4R0R479 · A0A4R0R479_9APHY
- ProteinHistone acetyltransferase type B catalytic subunit
- GeneHAT1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids501 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Catalytic activity
- acetyl-CoA + L-lysyl-[protein] = CoA + H+ + N6-acetyl-L-lysyl-[protein]
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 227 | Interaction with histone H4 N-terminus | ||||
Sequence: W | ||||||
Binding site | 272-274 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: FVI | ||||||
Binding site | 279-285 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: QQEGHGS | ||||||
Active site | 307 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 319 | acetyl-CoA (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | histone binding | |
Molecular Function | histone H4 acetyltransferase activity | |
Biological Process | subtelomeric heterochromatin formation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone acetyltransferase type B catalytic subunit
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Steccherinaceae > Steccherinum
Accessions
- Primary accessionA0A4R0R479
Proteomes
Interaction
Subunit
Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 70-215 | Histone acetyl transferase HAT1 N-terminal | ||||
Sequence: QIFGEDEKFYGYKDLVVDLKFASGSLAQYVKISYADKLPSSSAVDNIEDTLAQFIPPGYYKSEAEFTKRVEEDATTFKPYGTLIHSYSRSARKMSSGRKNASLPQPVYNPNDDEIVEFEVYHAKWDTPGFREYHRRMQIFILLYIE | ||||||
Region | 74-76 | Interaction with histone H4 N-terminus | ||||
Sequence: EDE | ||||||
Region | 256-258 | Interaction with histone H4 N-terminus | ||||
Sequence: YPF | ||||||
Region | 339-410 | Disordered | ||||
Sequence: DFTNSGRASPAHHPSPLLNGNGHNGHGGGGGGGGRVARSRTTHHERSVPLGSNGHGGAGASARRKTLGKMGP |
Sequence similarities
Belongs to the HAT1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length501
- Mass (Da)57,309
- Last updated2019-07-31 v1
- Checksum09B178F1B9C8EE3D
Keywords
- Technical term