A0A4R0P8Z7 · A0A4R0P8Z7_9HYPH
- ProteinDNA topoisomerase 4 subunit B
- GeneparE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids685 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 46 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 86 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 113 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 155-161 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLHGVGI | ||||||
Binding site | 386 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Site | 500 | Interaction with DNA | ||||
Sequence: N | ||||||
Site | 552 | Interaction with DNA | ||||
Sequence: H | ||||||
Site | 669 | Interaction with DNA | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Oricola
Accessions
- Primary accessionA0A4R0P8Z7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-47 | Disordered | ||||
Sequence: MDNSTDLFGGQPQADKPAEAAPQPARARKPAASPAAKPETDPNGGYD | ||||||
Domain | 466-580 | Toprim | ||||
Sequence: AEIFIVEGDSAGGSAKQARDRRTQAILPLRGKILNVASAGRDKLLANQQISDLIQALGCGTRGKYREADLRYERVIIMTDADVDGAHIASLLITFFYSEMPELIREGHLFLAVPP |
Sequence similarities
Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length685
- Mass (Da)74,910
- Last updated2019-07-31 v1
- ChecksumB6FC1F4FD216F8BB
Keywords
- Technical term