A0A4R0P8Z7 · A0A4R0P8Z7_9HYPH

  • Protein
    DNA topoisomerase 4 subunit B
  • Gene
    parE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

168550100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site46ATP (UniProtKB | ChEBI)
Binding site86ATP (UniProtKB | ChEBI)
Binding site113ATP (UniProtKB | ChEBI)
Binding site155-161ATP (UniProtKB | ChEBI)
Binding site386ATP (UniProtKB | ChEBI)
Site500Interaction with DNA
Site552Interaction with DNA
Site669Interaction with DNA

GO annotations

AspectTerm
Cellular Componentchromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit B
  • EC number
  • Alternative names
    • Topoisomerase IV subunit B

Gene names

    • Name
      parE
    • ORF names
      E0D97_15385

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KCTC 52183
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Ahrensiaceae > Oricola

Accessions

  • Primary accession
    A0A4R0P8Z7

Proteomes

Subcellular Location

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-47Disordered
Domain466-580Toprim

Sequence similarities

Belongs to the type II topoisomerase GyrB family.
Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    685
  • Mass (Da)
    74,910
  • Last updated
    2019-07-31 v1
  • Checksum
    B6FC1F4FD216F8BB
MDNSTDLFGGQPQADKPAEAAPQPARARKPAASPAAKPETDPNGGYDASAIEILEGLEPVRRRPGMYIGGTDDKALHHLFAEVIDNSMDEAVAGHATFIEVALDADGYVSVADNGRGIPVDPHPRHRDKSALEVIMTTLHAGGKFDSKVYETSGGLHGVGISVVNALSDDLQVEVARNRRLYRQAFSRGHPVSRLEDLGDVQNRRGTKVRFHPDAEIFGKSARFEPARLYRMARSKAYLFGGVEIRWQCAPELIGEKDETPARAVFHFPGGLKDYLEASLGGEQKVTPEIFAGKGARPGGHGSVEWAITWHGGDGFVNSYCNTIPTHEGGTHEAGLRIALTRGLKAYAELTGNKRAASITTDDVMISAAAMLSVFVREPEFVGQTKDKLATTEAQRIVDTALRDAFDHWLADSPQQANALLDWVVERADERLRRRQEKEVNRKSAVRKLRLPGKLADCSQNSAAGAEIFIVEGDSAGGSAKQARDRRTQAILPLRGKILNVASAGRDKLLANQQISDLIQALGCGTRGKYREADLRYERVIIMTDADVDGAHIASLLITFFYSEMPELIREGHLFLAVPPLFKLTQGGRTLYARDDAHKDELLASEFTGRGKVEISRFKGLGEMSANQLKETTMDPAVRTLLRVEILEGQDDATKTAVDDLMGTKPESRFRFIQENAAFARDLDI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SJST01000007
EMBL· GenBank· DDBJ
TCD12451.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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