A0A4Q7E3A7 · A0A4Q7E3A7_9CYAN
- Protein2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- GeneispF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids161 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Catalytic activity
- 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
Cofactor
Note: Binds 1 divalent metal cation per subunit.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 10-12 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 12 | a divalent metal cation (UniProtKB | ChEBI) | |||
Site | 36 | Transition state stabilizer | |||
Binding site | 36-37 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 44 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 58-60 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Binding site | 134-137 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
Site | 135 | Transition state stabilizer | |||
Binding site | 144 | 4-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- EC number
- Short namesMECDP-synthase ; MECPP-synthase ; MECPS
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Leptolyngbyales > Leptolyngbyaceae > Leptolyngbya group > Leptolyngbya > Leptolyngbya iicbica
Accessions
- Primary accessionA0A4Q7E3A7
Proteomes
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)17,022
- Last updated2019-07-31 v1
- ChecksumBD015A9DBA70FD7F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QVFV01000005 EMBL· GenBank· DDBJ | RZM76492.1 EMBL· GenBank· DDBJ | Genomic DNA |