A0A4Q5DPC5 · A0A4Q5DPC5_9BACE

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site97Schiff-base intermediate with DXP
Binding site1581-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site184-1851-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site206-2071-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionsulfurtransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG
    • ORF names
      GA560_01685

Organism names

  • Taxonomic identifier
  • Strain
    • BIOML-A73
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Bacteroidaceae > Bacteroides

Accessions

  • Primary accession
    A0A4Q5DPC5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-251Thiazole synthase ThiG

Sequence similarities

Belongs to the ThiG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    27,409
  • Last updated
    2019-07-31 v1
  • Checksum
    942AB43CACBD8130
MEKLVIAGREFSSRLFLGTGKFNSNEVMEQAILASGTEMVTVAMKRIDMDNKEDDMLKHIIHPNIQLLPNTSGVRNAEEAIFAAQLAHEAFGTNWLKLEIHPDPRYLLPDSIETLKATEELVKLGFIVLPYCQADPVLCKRLEEAGAATVMPLGAPIGTNKGLQTKEFLQIIIEQAGIPVVVDAGIGAPSHAAEAMELGASAVLVNTAIAVAGNPVEMAKAFKAATEAGRQAYEAGLGLQAVDFVAEASSPLTAFLD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WDER01000002
EMBL· GenBank· DDBJ
KAB6086920.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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