A0A4Q4TRK8 · A0A4Q4TRK8_9PEZI
- ProteinEKC/KEOPS complex subunit GON7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids464 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Catalytic activity
- 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
Pathway
Amino-acid degradation; L-valine degradation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | 3-hydroxyisobutyrate dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Biological Process | valine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEKC/KEOPS complex subunit GON7
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariales incertae sedis > Monosporascus
Accessions
- Primary accessionA0A4Q4TRK8
Proteomes
Subcellular Location
Interaction
Subunit
Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-187 | 6-phosphogluconate dehydrogenase NADP-binding | |||
Domain | 204-324 | 3-hydroxyisobutyrate dehydrogenase-like NAD-binding | |||
Region | 358-379 | Disordered | |||
Compositional bias | 361-375 | Polar residues | |||
Region | 405-464 | Disordered | |||
Compositional bias | 450-464 | Acidic residues | |||
Sequence similarities
Belongs to the GON7 family.
Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)47,733
- Last updated2019-07-31 v1
- MD5 Checksum57764746754AB59D329BC66C1F331444
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 361-375 | Polar residues | |||
Compositional bias | 450-464 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QJNU01000057 EMBL· GenBank· DDBJ | RYP08657.1 EMBL· GenBank· DDBJ | Genomic DNA |