A0A4Q4TRK8 · A0A4Q4TRK8_9PEZI

  • Protein
    EKC/KEOPS complex subunit GON7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid degradation; L-valine degradation.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Function3-hydroxyisobutyrate dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Biological Processvaline catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    EKC/KEOPS complex subunit GON7
  • EC number

Gene names

    • ORF names
      DL764_001785

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 110550
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Xylariales incertae sedis > Monosporascus

Accessions

  • Primary accession
    A0A4Q4TRK8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain8-1876-phosphogluconate dehydrogenase NADP-binding
Domain204-3243-hydroxyisobutyrate dehydrogenase-like NAD-binding
Region358-379Disordered
Compositional bias361-375Polar residues
Region405-464Disordered
Compositional bias450-464Acidic residues

Sequence similarities

Belongs to the GON7 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    47,733
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    57764746754AB59D329BC66C1F331444
MPASPTDTVAFIGLGVMGYPMAKNLRTGLGPEKTLLICDVNTEALSSFQKEMDGKGPIGTVENAFVAVKAANTVITMLPGSDAVKAVYLDPQTGILAGAAAAVDERETGSQPEPKLIMECGTIETDTILSVAKAAEDVSATKLHNTLTFVDAPVSGGPMGAQAGTLTFMVGCQPAVSPQIFPVVKSYLQHMGNPDGIFLCGAVGAGTAFKIINNYLSAITSLAASEALNIGVKAGLDPKLLTDVINQSGGQCWVTSKSNPVPGVQENVPSSRGYEGGFRIELCAKVLGMGSRLAEAVGARTVLDKPTLQAFREAVADERYQAQHLPTVKSKLTATTAMPRAELRATYASPHNAPLSLATPLDLPASSSSSTSPPPAEKAEYLRGLRAATAALQERINGELTARMEEDKAREASAAGGGGGVAAVAGTDKGNGGKAGGGGAKKAAKDVDEDAEEENYGEEVVEDD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias361-375Polar residues
Compositional bias450-464Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QJNU01000057
EMBL· GenBank· DDBJ
RYP08657.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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