A0A4Q2KMM0 · A0A4Q2KMM0_9SPHN

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-22GTP (UniProtKB | ChEBI)
Binding site134-137GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionguanosine tetraphosphate binding
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      ETX26_07935

Organism names

  • Taxonomic identifier
  • Strain
    • AY-3R
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Erythrobacteraceae > Pelagerythrobacter

Accessions

  • Primary accession
    A0A4Q2KMM0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-187Tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    605
  • Mass (Da)
    67,369
  • Last updated
    2019-07-31 v1
  • Checksum
    AA4F6E610824E93B
MTDLARIRNFSIIAHIDHGKSTLADRLIQRCGGLTDREMSEQVLDNMDIERERGITIKAQTVRLNYTAKDGQTYELNLMDTPGHVDFAYEVSRSLAACEGALLVVDAAQGVEAQTLANVYQSIEHDHEIVPVINKIDLPAAEPEKVRAEIEDIIGIDASEAVLTSAKSGIGIEDTLEAIVAKIPPPKGDRDAPLKAMLVDSWYDPYLGVVILVRVMDGAIRKGLQVRFMQGGTQHLIDRVGAFTPKRVDLPEIGPGEIGFITAQIKEVEQARVGDTITTVKGGAEKALPGYKEVQPVVFCGLFPVDAADFEKLRESIGKLRLNDASFSYEMESSAALGFGFRCGFLGLLHLEIIQERLSREYDLDLITTAPSVVYRIRLGKTKNEEAKTIELHNPADYPDPNRIEWIEEPWIKATIYTPDEYLGSILKLCQDRRGIQTDLTYVGGRAQVTYELPLNEVVFDFYDRLKSISRGYASFDYEQIGLREGDLVKMNILVNNEPVDALSLIVHRSVAEERGRGMCERLKDLIPRHLFKIPIQAAIGGKVIARETIAALRKDVTAKCYGGDITRKKKLLEKQKKGKARMREYGNVSIPQEAFIAALRMGEE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SDPV01000001
EMBL· GenBank· DDBJ
RXZ66588.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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